Evidence map›Paper›PMID 25490941›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2015

Cognitive function and other non-motor features in non-demented Parkinson's disease motor subtypes.

Talia Herman, Aner Weiss, Marina Brozgol, Adi Wilf-Yarkoni, Nir Giladi, Jeffrey M Hausdorff

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. Article
  6. Review
  7. Lewy Body Dementia: An Overview of Promising Therapeutics.Current neurology and neuroscience reports · 2023
    Review
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  9. Review
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  13. Review
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  18. Article
  19. Frontal Tasks and Behavior in Rigid or Tremor-Dominant Parkinson Disease.American journal of Alzheimer's disease and other dementias · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Talia HermanDepartment of Neurology, Tel Aviv Sourasky Medical Center, Center for the Study of Movement, Cognition and Mobility, 6 Weizman Street, 64239, Tel Aviv, Israel.
Aner Weiss
Marina Brozgol
Adi Wilf-Yarkoni
Nir Giladi
Jeffrey M Hausdorff

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among patients with Parkinson's disease (PD), a wide range of non-motor symptoms (NMS) are evident. We assessed markers of NMS and explored their behavioral correlates with the tremor-dominant (TD) and postural instability gait difficulty (PIGD) subtypes. 110 non-demented patients with PD were evaluated and stratified into the PIGD and TD subtypes and, using stricter criteria, into predominant subgroups: p-PIGD (n = 31) and p-TD (n = 32). Non-motor signs that were assessed included cognitive function (pen and paper and a computerized battery), autonomic function (NMSQest and SCOPA-AUT), mood, and sleep. Health-related quality of life was evaluated using the PDQ-39. The p-PIGD subgroup had a higher score on the NMSQest (p = 0.033) and a higher score (i.e., worse) on the PDQ-39 (p-PIGD: 26.28 ± 12.47; p-TD: 16.93 ± 12.22; p = 0.004), compared to the p-TD subgroup, while these measures did not differ in the larger PIGD and TD group. The p-PIGD subgroup used more sleep medications compared to the p-TD subgroup (1.0 ± 1.39 vs. 0.41 ± 0.94, p = 0.05, respectively). Most cognitive scores were similar in both subgroups; however, the visuospatial components of the Montreal Cognitive Assessment and the computerized catch game were significantly worse among the p-PIGD subgroup. Mild associations were found between certain non-motor symptoms, but not cognitive function, and the PIGD score. Non-demented patients from the PIGD subtype experience more non-motor symptoms and poorer quality of life compared to the TD subtype. These findings suggest that the clinical management of non-motor and motor symptoms in patients with PD may be enhanced by a personalized approach.

Indexed as

CognitionAdultAffectAgedAged, 80 and overAntiparkinson AgentsCross-Sectional StudiesDisability EvaluationFemaleGaitHumansMaleMiddle AgedNeuropsychological TestsParkinson DiseasePostureAntiparkinson Agents

Identifiers

PMID25490941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.