ArticleThe Plant cell2014
The Arabidopsis cellulose synthase complex: a proposed hexamer of CESA trimers in an equimolar stoichiometry.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed, 183 citations in OpenAlex.
- Article
- Selected cell wall-associated components in plant defense responses against microbial pathogens.Frontiers in plant science · 2026Review
- Cellulose Synthesis in Cyanobacteria: Shared Pathways and Distinct Features with Bacteria and Plants.Plants (Basel, Switzerland) · 2025Review
- The putative endo-1,4-β-D-glucanase GLU3 regulates cellulose biosynthesis in barley roots.Plant physiology · 2025Article
- Cellulose synthase TaCESA7 negatively regulates wheat resistance to stripe rust by reducing cell wall lignification.Stress biology · 2025Article
- Harnessing Apple Cell Suspension Cultures in Bioreactors for Triterpene Production: Transcriptomic Insights into Biomass and Triterpene Biosynthesis.International journal of molecular sciences · 2025Article
- Structural and functional characterization of cellulose synthase proteins (CesA) in rice and their regulation via brassinosteroid signaling under arsenate stress.Plant cell reports · 2024Article
- Heterogeneity in Mechanical Properties of Plant Cell Walls.Plants (Basel, Switzerland) · 2024Review
- How Many Glucan Chains Form Plant Cellulose Microfibrils? A Mini Review.Biomacromolecules · 2024Review
- Reply to: Critical comment on the assumptions leading to 24-chain microfibrils in wood.Nature plants · 2024Article
- Atomistic, macromolecular model of theScience advances · 2024Article
- Comparative proteomic analysis provides insights into wood formation in immature xylem at different ages inFrontiers in plant science · 2024Article
- Tissue-specific directionality of cellulose synthase complex movement inferred from cellulose microfibril polarity in secondary cell walls of Arabidopsis.Scientific reports · 2023Article
- Actomyosin and CSI1/POM2 cooperate to deliver cellulose synthase from Golgi to cortical microtubules in Arabidopsis.Nature communications · 2023Article
- A chromosome-level genome assembly for Erianthus fulvus provides insights into its biofuel potential and facilitates breeding for improvement of sugarcane.Plant communications · 2023Article
- Wood cellulose microfibrils have a 24-chain core-shell nanostructure in seed plants.Nature plants · 2023Article
- Grazing-incidence diffraction reveals cellulose and pectin organization in hydrated plant primary cell wall.Scientific reports · 2023Article
- The cell biology of primary cell walls during salt stress.The Plant cell · 2023Review
- Essential amino acids in the Plant-Conserved and Class-Specific Regions of cellulose synthases.Plant physiology · 2023Article
- Structural differences of cell walls in earlywood and latewood ofFrontiers in plant science · 2023Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellulose is the most abundant renewable polymer on Earth and a major component of the plant cell wall. In vascular plants, cellulose synthesis is catalyzed by a large, plasma membrane-localized cellulose synthase complex (CSC), visualized as a hexameric rosette structure. Three unique cellulose synthase (CESA) isoforms are required for CSC assembly and function. However, elucidation of either the number or stoichiometry of CESAs within the CSC has remained elusive. In this study, we show a 1:1:1 stoichiometry between the three Arabidopsis thaliana secondary cell wall isozymes: CESA4, CESA7, and CESA8. This ratio was determined utilizing a simple but elegant method of quantitative immunoblotting using isoform-specific antibodies and (35)S-labeled protein standards for each CESA. Additionally, the observed equimolar stoichiometry was found to be fixed along the axis of the stem, which represents a developmental gradient. Our results complement recent spectroscopic analyses pointing toward an 18-chain cellulose microfibril. Taken together, we propose that the CSC is composed of a hexamer of catalytically active CESA trimers, with each CESA in equimolar amounts. This finding is a crucial advance in understanding how CESAs integrate to form higher order complexes, which is a key determinate of cellulose microfibril and cell wall properties.
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