ArticleJournal of hypertension2015
Metabolomic study of carotid-femoral pulse-wave velocity in women.
Article in Journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 58 citations in OpenAlex.
- Microbial metabolite-driven mechanisms linking the gut microbiome to atherosclerosis: multi-omic and translational perspectives.Gut microbes · 2026Review
- Changes in Phenylacetylglutamine Levels Provide Add-On Value in Risk Stratification of Hypertensive Patients: A Longitudinal Cohort Study.Metabolites · 2025Article
- Plasma Metabolome Predicts Aortic Stiffness and Future Risk of Coronary Artery Disease and Mortality After 23 Years of Follow-Up in the General Population.Journal of the American Heart Association · 2024Article
- Characteristics of pulmonary artery strain assessed by cardiovascular magnetic resonance imaging and associations with metabolomic pathways in human ageing.Frontiers in cardiovascular medicine · 2024Article
- Phenylacetylglutamine and trimethylamine N-oxide: Two uremic players, different actions.European journal of clinical investigation · 2023Observational
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- The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease.Nature reviews. Cardiology · 2023Review
- Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Association of amino acids and parameters of bone metabolism with endothelial dysfunction and vasculopathic changes in limited systemic sclerosis.Frontiers in medicine · 2023Article
- Combined analysis of plasma metabolome and intestinal microbiome sequencing to explore jiashen prescription and its potential role in changing intestine-heart axis and effect on chronic heart failure.Frontiers in cardiovascular medicine · 2023Article
- Diagnosing Arterial Stiffness in Pregnancy and Its Implications in the Cardio-Renal-Metabolic Chain.Diagnostics (Basel, Switzerland) · 2022Review
- Phenylacetylglutamine as a risk factor and prognostic indicator of heart failure.ESC heart failure · 2022Article
- Cross-Sectional Blood Metabolite Markers of Hypertension: A Multicohort Analysis of 44,306 Individuals from the COnsortium of METabolomics Studies.Metabolites · 2022Article
- Metabolomics of Arterial Stiffness.Metabolites · 2022Review
- Prognostic value of plasma phenylalanine and gut microbiota-derived metabolite phenylacetylglutamine in coronary in-stent restenosis.Frontiers in cardiovascular medicine · 2022Article
- Associations between circulating metabolites and arterial stiffness.Journal of human hypertension · 2021Article
- Elevated levels of urine isocitrate, hydroxymethylglutarate, and formiminoglutamate are associated with arterial stiffness in Korean adults.Scientific reports · 2021Article
- Traditional Bulgarian Dairy Products: Ethnic Foods with Health Benefits.Microorganisms · 2021Review
- Phenylacetylglutamine, a Novel Biomarker in Acute Ischemic Stroke.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveCarotid-femoral pulse-wave velocity (PWV) is a measure of aortic stiffness that is strongly associated with increased risk of cardiovascular morbidity and mortality. The aim of the current study was to identify the molecular markers and the pathways involved in differences in PWV in women, in order to further understand the regulation of arterial stiffening.
methodsA total of 280 known metabolites were measured in 1797 female twins (age range: 18-84 years) not on any antihypertensive medication. Metabolites associated with PWV (after adjustment for age, BMI, metabolite batch, and family relatedness) were entered into a backward linear regression. Transcriptomic analyses were further performed on the top compounds identified.
resultsTwelve metabolites were associated with PWV (P < 1.8 × 10). One of the most strongly associated metabolites was uridine, which was not associated with blood pressure (BP) and traditional risk factors but correlated significantly with the gene-expression levels of the purinergic receptor P2RY2 (Beta = -0.010, SE = 0.003, P = 0.007), suggesting that it may play a role in regulating endothelial nitric oxide synthase phosphorylation. On the other hand, phenylacetylglutamine was strongly associated with both PWV and BP.
conclusionCirculating levels of uridine, phenylacetylglutamine, and serine appear strongly correlated with PWV in women.
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