ReviewMolecules (Basel, Switzerland)2014
Alkaloids from marine invertebrates as important leads for anticancer drugs discovery and development.
Review in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Study of Cytotoxicity of Pyrrolo[3,4-International journal of molecular sciences · 2026Article
- Enhancing cancer treatment with marine algae-derived bioactive chemicals: a review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Marine Natural Products in Preclinical Cancer Studies: Ten Years of Advanced Total Synthesis.Marine drugs · 2025Review
- Performance of Green Desymmetrization Methods toward Bioactive Cephalostatin Analogues.Current medicinal chemistry · 2024Review
- The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target.Oncogene · 2022Review
- Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery.Molecules (Basel, Switzerland) · 2022Review
- Computer-Aided Drug Design (CADD) to De-Orphanize Marine Molecules: Finding Potential Therapeutic Agents for Neurodegenerative and Cardiovascular Diseases.Marine drugs · 2022Article
- Bioactive natural products from marine sponges belonging to family Hymedesmiidae.RSC advances · 2021Review
- Natural Compounds as Therapeutic Agents: The Case of Human Topoisomerase IB.International journal of molecular sciences · 2021Review
- Naturally Inspired Pyrimidines Analogues for Alzheimer's Disease.Current neuropharmacology · 2021Review
- Therapeutic value of steroidal alkaloids in cancer: Current trends and future perspectives.International journal of cancer · 2019Review
- HFIP-Promoted Bischler Indole Synthesis under Microwave Irradiation.Molecules (Basel, Switzerland) · 2018Article
- Chaetominine induces cell cycle arrest in human leukemia K562 and colon cancer SW1116 cells.Oncology letters · 2018Article
- Ascidian Toxins with Potential for Drug Development.Marine drugs · 2018Review
- A new approach to alkaloid-like systems: synthesis and crystal structure of 1-(2-acetyl-11-meth-oxy-5,6-di-hydro-[1,3]dioxolo[4,5-Acta crystallographica. Section E, Crystallographic communications · 2017Article
- Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core.Marine drugs · 2017Article
- Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats.Journal of food science and technology · 2017Article
- Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem".Marine drugs · 2016Review
- Combinations of alkaloids affecting different molecular targets with the saponin digitonin can synergistically enhance trypanocidal activity against Trypanosoma brucei brucei.Antimicrobial agents and chemotherapy · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.
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