ArticlePloS one2014
In-hospital and one-year mortality and their predictors in patients hospitalized for first-ever chronic obstructive pulmonary disease exacerbations: a nationwide population-based study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Could patients with chronic obstructive pulmonary disease benefit from renin angiotensin system inhibitors? A meta-analysis.BMJ open respiratory research · 2023Pooled it
- Predictors of mortality in chronic obstructive pulmonary disease: a systematic review and meta-analysis.BMC pulmonary medicine · 2022Pooled it
- The prevalence and clinical features of pulmonary embolism in patients with AE-COPD: A meta-analysis and systematic review.PloS one · 2021Pooled it
- Effect of short-term oral prednisone therapy on blood gene expression: a randomised controlled clinical trial.Respiratory research · 2019Trial
- Trial
- Chronic Obstructive Pulmonary Disease Hospitalization in Spain (2016-2023): Mortality Impact of Comorbidity, Sex-Based Disparities and the Impact of COVID-19.Journal of personalized medicine · 2026Article
- The MAGENTA Model for Individual Prediction of In-Hospital Mortality in Chronic Obstructive Pulmonary Disease With Acute Exacerbation: An External Validation Study.Journal of clinical medicine research · 2026Article
- Compounding risks of chronic health conditions and substance use disorder on healthcare burden in the USA: Analysis of NSDUH data (2021-2023).Addictive behaviors reports · 2025Article
- Proactive Strategies for Mitigating Cardiopulmonary Risk in COPD.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- Improving Care for People with Chronic Respiratory Diseases: Taking a Policy Lens.Advances in therapy · 2025Review
- Knowledge, attitudes, and practices of COPD patients regarding acute exacerbations of COPD.Frontiers in medicine · 2025Article
- Validation Study of Rome Criteria for Assessing COPD Exacerbation Severity and Predicting Clinical Outcomes: Turkish Thoracic Society COPD Assembly.International journal of chronic obstructive pulmonary disease · 2025Article
- Recommendations for Improving Discharge-Related Care Following a COPD Exacerbation: An Expert Panel Consensus with Emphasis on Low- and Middle-Income Countries.International journal of chronic obstructive pulmonary disease · 2025Article
- Factors Influencing Mechanical Ventilation and Inpatient Palliative Care Utilization in Patients With Chronic Obstructive Pulmonary Disease.Journal of multidisciplinary healthcare · 2025Article
- Mobile App for Patients With Chronic Obstructive Pulmonary Diseases During Home-Based Exercise Care: Usability Study.JMIR human factors · 2024Article
- Improving COPD Management at Transitions of Care.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024Article
- The impact of comorbidities on prolonged mechanical ventilation in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2024Article
- Mortality prevention as the centre of COPD management.ERJ open research · 2024Review
- Machine learning approaches for practical predicting outpatient near-future AECOPD based on nationwide electronic medical records.iScience · 2024Article
- The Long-Term Impact of Frailty After an Intensive Care Unit Admission Due to Chronic Obstructive Pulmonary Disease.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionNatural history of chronic obstructive pulmonary disease (COPD) is punctuated by exacerbations; however, little is known about prognosis of the first-ever COPD exacerbation and variables predicting its outcomes. MATERIALS AND
methodsA population-based cohort study among COPD patients with their first-ever exacerbations requiring hospitalizations was conducted. Main outcomes were in-hospital mortality and one-year mortality after discharge. Demographics, comorbidities, medications and in-hospital events were obtained to explore outcome predictors.
resultsThe cohort comprised 4204 hospitalized COPD patients, of whom 175 (4%) died during the hospitalization. In-hospital mortality was related to higher age (odds ratio [OR]: 1.05 per year; 95% confidence interval [CI]: 1.03-1.06) and Charlson comorbidity index score (OR: 1.08 per point; 95% CI: 1.01-1.15); angiotensin II receptor blockers (OR: 0.61; 95% CI: 0.38-0.98) and β blockers (OR: 0.63; 95% CI: 0.41-0.95) conferred a survival benefit. At one year after discharge, 22% (871/4029) of hospital survivors were dead. On multivariate Cox regression analysis, age and Charlson comorbidity index remained independent predictors of one-year mortality. Longer hospital stay (hazard ratio [HR] 1.01 per day; 95% CI: 1.01-1.01) and ICU admission (HR: 1.33; 95% CI: 1.03-1.73) during the hospitalization were associated with higher mortality risks. Prescription of β blockers (HR: 0.79; 95% CI: 0.67-0.93) and statins (HR: 0.66; 95% CI: 0.47-0.91) on hospital discharge were protective against one-year mortality.
conclusionsEven the first-ever severe COPD exacerbation signifies poor prognosis in COPD patients. Comorbidities play a crucial role in determining outcomes and should be carefully assessed. Angiotensin II receptor blockers, β blockers and statins may, in theory, have dual cardiopulmonary protective properties and probably alter prognosis of COPD patients. Nevertheless, the limitations inherent to a claims database study, such as the diagnostic accuracy of COPD and its exacerbation, should be born in mind.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.