Evidence map›Paper›PMID 25489850›Full record

ArticlePloS one2014

School-located influenza vaccination reduces community risk for influenza and influenza-like illness emergency care visits.

Cuc H Tran, Jonathan D Sugimoto, Juliet R C Pulliam, Kathleen A Ryan, Paul D Myers, Joan B Castleman, Randell Doty, Jackie Johnson, Jim Stringfellow, Nadia Kovacevich and 11 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02975596 (Establishing and Evaluating a School and University Campus-Based Approach to Implementing Serogroup B Meningococcal), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02975596 nacompletednot on this mapstarted 2016, after this paper: background citation

Establishing and Evaluating a School and University Campus-Based Approach to Implementing Serogroup B Meningococcal (MenB) Disease Recommendations in Older Adolescents and Young Adults.

TypeinterventionalSponsorUniversity of FloridaRan2016 to 2019Enrolled1,326ConditionsMeningococcal VaccineArmsAwareness, Education, Empowerment, Accessibility
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  8. Observational
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  11. Improving Influenza Vaccination Coverage Among Patients With COPD: A Pilot Project.International journal of chronic obstructive pulmonary disease · 2019
    Article
  12. Article
  13. Optimizing the impact of low-efficacy influenza vaccines.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  14. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 5 institutions in 1 country.

Cuc H TranDepartment of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Clinical Translational Science Institute, University of Florida, Gainesville, Florida, United States of America.
Jonathan D SugimotoEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America; Department of Epidemiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
Juliet R C PulliamEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Biology, College of Liberal Arts and Sciences, University of Florida, Gainesville, Florida, United States of America; Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America.
Kathleen A RyanEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
Paul D MyersFlorida Department of Health in Alachua County, Gainesville, Florida, United States of America.
Joan B CastlemanCollege of Nursing, University of Florida, Gainesville, Florida, United States of America.
Randell DotyCollege of Pharmacy, University of Florida, Gainesville, Florida, United States of America.
Jackie JohnsonAlachua County Public Schools, Gainesville, Florida, United States of America.
Jim StringfellowPartnership for Strong Families, Gainesville, Florida, United States of America.
Nadia KovacevichFlorida Department of Health in Alachua County, Gainesville, Florida, United States of America.
Joe BrewDepartment of Epidemiology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America; Department of Epidemiology, College of Medicine, University of Florida, Gainesville, Florida, United States of America; Florida Department of Health in Alachua County, Gainesville, Florida, United States of America.
Lai Ling CheungEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.
Brad CaronFlorida Department of Health in Alachua County, Gainesville, Florida, United States of America.
Gloria LiporiUniversity of Florida Health Integrated Data Repository, UF Health, Gainesville, Florida, United States of America.
Christopher A HarleClinical Translational Science Institute, University of Florida, Gainesville, Florida, United States of America; Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America.
Charles AlexanderFlorida Department of Health, Tallahassee, Florida, United States of America.
Yang YangEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America; Department of Biostatistics, Colleges of Medicine, University of Florida, Gainesville, Florida, United States of America.
Ira M LonginiEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, United States of America; Department of Biostatistics, Colleges of Medicine, University of Florida, Gainesville, Florida, United States of America.
M Elizabeth HalloranVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America; Department of Biostatistics, University of Washington, Seattle, Washington, United States of America.
J Glenn MorrisEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
Parker A SmallEmerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America; Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, United States of America; Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, United States of America.
University of Florida · USFlorida Department of Health · USFogarty International Center · USFred Hutch Cancer Center · USUniversity of Florida Health · US

Funding

Understanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPMAN, JAMES STEPHEN · 2014 to 2018
$12.5M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Containing Bioterrorist and Emerging Infectious DiseasesU01GM070749 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH, LONGINI, IRA M · 2004 to 2013
$8.3M
Methods for Evaluating Vaccine EfficacyR37AI032042 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH · 2010 to 2019
$5.1M
UF Clinical and Translational Science AwardKL2TR000065 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$1.6M
UF Clinical and Translational Science AwardTL1TR000066 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$345k
NCATS NIH HHS KL2 TR000065NCATS NIH HHS KL2TR000065NCATS NIH HHS TL1 TR000066NCATS NIH HHS TL1TR000066NCATS NIH HHS UL1 TR000064NIAID NIH HHS R37 AI032042NIGMS NIH HHS U01 GM070749NIGMS NIH HHS U54 GM111274
6 · The paper itself

Abstract

backgroundSchool-located influenza vaccination (SLIV) programs can substantially enhance the sub-optimal coverage achieved under existing delivery strategies. Randomized SLIV trials have shown these programs reduce laboratory-confirmed influenza among both vaccinated and unvaccinated children. This work explores the effectiveness of a SLIV program in reducing the community risk of influenza and influenza-like illness (ILI) associated emergency care visits.

methodsFor the 2011/12 and 2012/13 influenza seasons, we estimated age-group specific attack rates (AR) for ILI from routine surveillance and census data. Age-group specific SLIV program effectiveness was estimated as one minus the AR ratio for Alachua County versus two comparison regions: the 12 county region surrounding Alachua County, and all non-Alachua counties in Florida.

resultsVaccination of ∼50% of 5-17 year-olds in Alachua reduced their risk of ILI-associated visits, compared to the rest of Florida, by 79% (95% confidence interval: 70, 85) in 2011/12 and 71% (63, 77) in 2012/13. The greatest indirect effectiveness was observed among 0-4 year-olds, reducing AR by 89% (84, 93) in 2011/12 and 84% (79, 88) in 2012/13. Among all non-school age residents, the estimated indirect effectiveness was 60% (54, 65) and 36% (31, 41) for 2011/12 and 2012/13. The overall effectiveness among all age-groups was 65% (61, 70) and 46% (42, 50) for 2011/12 and 2012/13.

conclusionWider implementation of SLIV programs can significantly reduce the influenza-associated public health burden in communities.

Indexed as

AdolescentAmbulatory Care FacilitiesChildChild, PreschoolEmergency Medical ServicesEmergency Service, HospitalFemaleFloridaHumansImmunization ProgramsInfluenza, HumanMaleResidence CharacteristicsRiskSchoolsVaccination

Identifiers

PMID25489850
PMCPMC4260868
OpenAlexW2035794216

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.