Evidence map›Paper›PMID 25489630›Full record

Trial reportEpilepsia2015

Better object recognition and naming outcome with MRI-guided stereotactic laser amygdalohippocampotomy for temporal lobe epilepsy.

Daniel L Drane, David W Loring, Natalie L Voets, Michele Price, Jeffrey G Ojemann, Jon T Willie, Amit M Saindane, Vaishali Phatak, Mirjana Ivanisevic, Scott Millis and 4 more

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Epilepsia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 8 pooled it
16.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 8 syntheses or guidelines pooled it, 327 citations in OpenAlex.

  1. Pooled it
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  9. Trial
  10. Article
  11. Review
  12. Article
  13. MRI-guided laser ablation for pediatric intracranial pathology: single center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  14. Review
  15. Article
  16. Article
  17. Exploring individual differences in amygdala-mediated memory modulation.Cognitive, affective & behavioral neuroscience · 2025
    Article
  18. Article
  19. Article
  20. Article

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Daniel L DraneDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, U.S.A; Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, U.S.A; Department of Neurology, University of Washington School of Medicine, Seattle, Washington, U.S.A.
David W Loring
Natalie L Voets
Michele Price
Jeffrey G Ojemann
Jon T Willie
Amit M Saindane
Vaishali Phatak
Mirjana Ivanisevic
Scott Millis
Sandra L Helmers
John W Miller
Kimford J Meador
Robert E Gross
Emory University · USNeurological Surgery · USUniversity of Washington · USWayne State University · USWellcome Centre for Integrative Neuroimaging · GB

Funding

Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD)U01NS038455 · NINDS · STANFORD UNIVERSITY · PI MATTHEWS, ABIGAIL GOREN, MEADOR, KIMFORD J · 2012 to 2022
$27.7M
Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Characterizing and Predicting Drug Effects on CognitionR01NS076665 · NINDS · UNIVERSITY OF MINNESOTA · PI MARINO, SUSAN E · 2012 to 2016
$2.7M
Semantic Deficits in Temporal Lobe Epilepsy Surgical Patients May Represent A StrK02NS070960 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2011 to 2015
$827k
Category-Specific Naming and Recognition in EpilepsyK23NS049100 · NINDS · UNIVERSITY OF WASHINGTON · PI DRANE, DANIEL L · 2005 to 2009
$709k
Medical Research Council G0900806NINDS NIH HHS 2U01-NS038455-11A1NINDS NIH HHS K02 NS070960NINDS NIH HHS K23 NS049100NINDS NIH HHS R01 NS076665NINDS NIH HHS R01 NS076665-01A1NINDS NIH HHS R01 NS088748NINDS NIH HHS R01NS088748NINDS NIH HHS U01 NS038455PHS HHS K23 NSO49100
6 · The paper itself

Abstract

objectivesPatients with temporal lobe epilepsy (TLE) experience significant deficits in category-related object recognition and naming following standard surgical approaches. These deficits may result from a decoupling of core processing modules (e.g., language, visual processing, and semantic memory), due to "collateral damage" to temporal regions outside the hippocampus following open surgical approaches. We predicted that stereotactic laser amygdalohippocampotomy (SLAH) would minimize such deficits because it preserves white matter pathways and neocortical regions that are critical for these cognitive processes.

methodsTests of naming and recognition of common nouns (Boston Naming Test) and famous persons were compared with nonparametric analyses using exact tests between a group of 19 patients with medically intractable mesial TLE undergoing SLAH (10 dominant, 9 nondominant), and a comparable series of TLE patients undergoing standard surgical approaches (n=39) using a prospective, nonrandomized, nonblinded, parallel-group design.

resultsPerformance declines were significantly greater for the patients with dominant TLE who were undergoing open resection versus SLAH for naming famous faces and common nouns (F=24.3, p<0.0001, η2=0.57, and F=11.2, p<0.001, η2=0.39, respectively), and for the patients with nondominant TLE undergoing open resection versus SLAH for recognizing famous faces (F=3.9, p<0.02, η2=0.19). When examined on an individual subject basis, no SLAH patients experienced any performance declines on these measures. In contrast, 32 of the 39 patients undergoing standard surgical approaches declined on one or more measures for both object types (p<0.001, Fisher's exact test). Twenty-one of 22 left (dominant) TLE patients declined on one or both naming tasks after open resection, while 11 of 17 right (nondominant) TLE patients declined on face recognition. SIGNIFICANCE: Preliminary results suggest (1) naming and recognition functions can be spared in TLE patients undergoing SLAH, and (2) the hippocampus does not appear to be an essential component of neural networks underlying name retrieval or recognition of common objects or famous faces.

Indexed as

Recognition, PsychologyAdultAmygdalaEpilepsy, Temporal LobeFaceFunctional LateralityHippocampusHumansLanguageLanguage DisordersLaser TherapyMagnetic Resonance ImagingMemory DisordersMiddle AgedNeuropsychological TestsPattern Recognition, VisualCognitive outcomeEpilepsy surgeryFamous facesLaser interstitial thermal therapyNaming and recognition

Identifiers

PMID25489630
PMCPMC4446987
OpenAlexW2020888576

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.