ReviewMuscles, ligaments and tendons journal2014
Growth factor delivery vehicles for tendon injuries: Mesenchymal stem cells and Platelet Rich Plasma.
Review in Muscles, ligaments and tendons journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells.Stem cells international · 2025Article
- The current status of various preclinical therapeutic approaches for tendon repair.Annals of medicine · 2024Review
- Curcumin Improves Functional Recovery of Ruptured Tendon by Promoting Tenogenesis via PI3K/Akt Signaling.Stem cells translational medicine · 2024Article
- The Cincinnati incision is safe and effective for revision surgery for insertional tendinopathy of the Achilles tendon.Scientific reports · 2022Article
- Failed Surgery for Patellar Tendinopathy in Athletes: Midterm Results of Further Surgical Management.Orthopaedic journal of sports medicine · 2021Article
- A pilot study: effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence.Scientific reports · 2021Article
- Basic Research on Tendon Repair: Strategies, Evaluation, and Development.Frontiers in medicine · 2021Review
- Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds.Stem cells international · 2021Review
- Intra-ovarian injection of platelet-rich plasma into ovarian tissue promoted rejuvenation in the rat model of premature ovarian insufficiency and restored ovulation rate via angiogenesis modulation.Reproductive biology and endocrinology : RB&E · 2020Article
- Adaptive and innate immune cell responses in tendons and lymph nodes after tendon injury and repair.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Biomaterials for the Treatment of Tendon Injury.Tissue engineering and regenerative medicine · 2019Review
- An animal experimental study on pubourethral ligament restoration with platelet rich plasma for the treatment of stress urinary incontinence.Central European journal of urology · 2019Article
- A Systematic Summary of Systematic Reviews on the Topic of the Rotator Cuff.Orthopaedic journal of sports medicine · 2018Review
- Adult Cells Combined With Platelet-Rich Plasma for Tendon Healing: Cell Source Options.Orthopaedic journal of sports medicine · 2017Article
- A Clinical, Biological, and Biomaterials Perspective into Tendon Injuries and Regeneration.Tissue engineering. Part B, Reviews · 2017Article
- Ultrasound-guided procedures to treat sport-related muscle injuries.The British journal of radiology · 2016Review
- Combining mesenchymal stem cell sheets with platelet-rich plasma gel/calcium phosphate particles: a novel strategy to promote bone regeneration.Stem cell research & therapy · 2015Article
- Tendon injury: from biology to tendon repair.Nature reviews. Rheumatology · 2015Review
- Lactoferrin and parathyroid hormone are not harmful to primary tenocytesMuscles, ligaments and tendons journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundtendon tissue shows limited regeneration potential with formation of scar tissue and inferior mechanical properties. The capacity of several growth factors to improve the healing response and decrease scar formation is described in different preclinical studies. Besides the application of isolated growth factors, current research focuses on two further strategies to improve the healing response in tendon injuries: platelet rich plasma (PRP) and mesenchymal stem cells (MSCs).
objectivethe present review focuses on these two options and describes their potential to improve tendon healing.
resultsin vitro experiments and animal studies showed promising results for the use of PRP, however clinical controlled studies have shown a tendency of reduced pain related symptoms but no significant differences in overall clinical scores. On the other hand MSCs are not totally arrived in clinical use so that there is still a lack of randomized controlled trials. In basic research experiments they show an extraordinary paracrine activity, anti-inflammatory effect and the possibility to differentiate in tenocytes when different activating-factors are added.
conclusionpreclinical studies have shown promising results in improving tendon remodeling but the comparability of current literature is difficult due to different compositions. PRP and MSCs can act as efficient growth factor vehicles, however further studies should be performed in order to adequate investigate their clinical benefits in different tendon pathologies.
Indexed as
Identifiers
25489557PMC4241431W2327906432What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.