ArticleMuscles, ligaments and tendons journal2014
Angiogenic and innate immune responses triggered by PRP in tendon cells are not modified by hyperuricemia.
Article in Muscles, ligaments and tendons journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Effect of Bone Marrow Aspirate Concentrate-Platelet-Rich Plasma on Tendon-Derived Stem Cells and Rotator Cuff Tendon Tear.Cell transplantation · 2017Trial
- Platelet-Rich Fibrin Increases CXCL8 Expression in Gingival Fibroblasts.Biomedicines · 2024Article
- Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells.Stem cells international · 2022Article
- Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia.Journal of oncology · 2022Article
- Effectiveness of Amniotic Fluid Injection in the Treatment of Trigger Finger: A Pilot Study.Journal of hand surgery global online · 2020Article
- Angiogenic effect of platelet-rich concentrates on dental pulp stem cells in inflamed microenvironment.Clinical oral investigations · 2019Article
- Some patients (and some of us) respond better to some biological therapies: the as yet unsolved conundrum.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2018Article
- An Untypical Case of Gouty Infiltration of Both Peroneal Tendons and a Longitudinal Lesion of the Peroneus Brevis Tendon Mimicking Synovial Sarcoma.Case reports in orthopedics · 2018Article
- PRP Treatment Efficacy for Tendinopathy: A Review of Basic Science Studies.BioMed research international · 2016Review
- Platelet-rich plasma modulates the secretion of inflammatory/angiogenic proteins by inflamed tenocytes.Clinical orthopaedics and related research · 2015Article
- Hyperuricemic PRP in tendon cells.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundhyperuricemia is becoming a critical medical problem, and a current focus of research. Uric acid is also a death cell associated stressor that may trigger innate immune responses via the synthesis of inflammatory and angiogenic proteins. PURPOSE: to investigate the angiogenic/inflammatory protein profile of tendon cells treated with Platelet Rich Plasma (PRP), and to assess if there are any differences in synthesis of angiogenic/inflammatory cytokines between PRP-treated or hyperuricemic PRP-treated cells.
methodstendon cells were treated with PRP or hyperuricemic PRP and cell culture supernatants examined using glass based protein arrays for inflammation and angiogenesis. Relevant proteins were subsequently quantified by ELISA or EASIA methods.
resultsthe impact of PRP on angiogenesis and inflammation is evidenced by relevant cytokine synthesis including: Monocyte Chemoattractant Protein (MCP-1/CCL2), Regulated upon Activation Normally T cells Expressed and Secreted (RANTES/CCL5), IL-6/CXCL6, IL-8/CXCL8, Vascular Endothelial Growth Factor (VEGF), Growth Regulated Protein (GRO-a/CXCL1) and Hepatocyte Growth Factor (HGF). IL-1beta was not detected in these conditions. Taken together these data suggest an initial angiogenetic and innate immune responses driven by chemokines that is not altered by the presence of hyperuricemia, at this point, except for IL-8 secretion, p= 0.042.
Indexed as
Identifiers
25489545PMC4241418W2052209291What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.