ArticleMuscles, ligaments and tendons journal2014
Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes.
Article in Muscles, ligaments and tendons journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Assessment of the Musculoskeletal Axis and Body Composition Parameters in Women with Controlled Thyroid Dysfunction: A Cross-Sectional Study.Metabolites · 2026Article
- Ovothiol-A Exhibited Protective and Therapeutic Effect against Hyperthyroidism in Rats.Current topics in medicinal chemistry · 2025Article
- Recent developments in Achilles tendon risk-analyzing rupture factors for enhanced injury prevention and clinical guidance: Current implications of regenerative medicine.Journal of orthopaedic translation · 2024Review
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- Preparing the soil: Adjusting the metabolic health of patients with chronic wounds and musculoskeletal diseases.International wound journal · 2024Review
- Factors associated with long head of the biceps tendon tear severity and predictive insights for grade II tears in rotator cuff surgery.Clinics in shoulder and elbow · 2024Article
- The tendon unit: biochemical, biomechanical, hormonal influences.Journal of orthopaedic surgery and research · 2023Review
- CD200 as a Potential New Player in Inflammation during Rotator Cuff Tendon Injury/Repair: An In Vitro Model.International journal of molecular sciences · 2022Article
- Article
- Hyaluronic Acid Alleviates Oxidative Stress and Apoptosis in Human Tenocytes via Caspase 3 and 7.International journal of molecular sciences · 2022Article
- Achilles Tendon Rupture and Dysmetabolic Diseases: A Multicentric, Epidemiologic Study.Journal of clinical medicine · 2022Article
- Article
- Combined ascorbic acid and TJournal of orthopaedic surgery and research · 2019Article
- What is the role of systemic conditions and options for manipulation of bone formation and bone resorption in rotator cuff tendon healing and repair?Techniques in shoulder & elbow surgery · 2017Article
- Imbalances in the Development of Muscle and Tendon as Risk Factor for Tendinopathies in Youth Athletes: A Review of Current Evidence and Concepts of Prevention.Frontiers in physiology · 2017Review
- The Role of Detraining in Tendon Mechanobiology.Frontiers in aging neuroscience · 2016Review
- Hyaluronic acid increases tendon derived cell viability and collagen type I expression in vitro: Comparative study of four different Hyaluronic acid preparations by molecular weight.BMC musculoskeletal disorders · 2015Article
- Combined supplementation of ascorbic acid and thyroid hormone TMuscles, ligaments and tendons journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundwe previously demonstrated the presence of high levels of thyroid hormones (THs) receptors isoforms in healthy tendons, their protective action during tenocyte apoptosis, and the capability to enhance tenocyte proliferation in vitro. In the present study we tested the ability of THs to influence ECM protein tenocyte secretion in an in vitro system.
methodsprimary tenocyte-like cells were cultivated for 1, 7 and 14 days in the presence of T3 or T4 individually or in combination with ascorbic acid (AA).
resultsTHs (T3 or T4) in synergism with AA increase significantly the total collagen production after 14 days. THs in synergism with AA increase significantly the expression of collagen I,biglycan and COMP, after some days.
conclusionTHs play a role on the extra cellular matrix of tendons, enhancing in vitro the production of several proteins such as collagen I, biglycan and COMP. THs receptors are active on human tenocytes, and can play a role in tendon ailments.
Indexed as
Identifiers
25489544PMC4241417W1971012812What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.