ArticleMuscles, ligaments and tendons journal2014
Biomechanical properties and histology of db/db diabetic mouse Achilles tendon.
Article in Muscles, ligaments and tendons journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The association between diabetes mellitus and musculoskeletal disorders: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Serum Advanced Glycation End Products as Drivers of Poor Tendon Outcomes in Diabetes? An Emerging Hypothesis and Narrative Review.Endocrinology, diabetes & metabolism · 2026Review
- Characterizing tendon microstructure using metrics associated with the angular dependence of ultrasound backscatter.The Journal of the Acoustical Society of America · 2026Article
- The impact of type 2 diabetes on tendon material properties and locomotor function in the db/db mouse.Experimental physiology · 2026Article
- Exploring the Intersection of Diabetes and Musculoskeletal Health : Diabetes and Musculoskeletal Health.Galen medical journal · 2025Review
- Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Impact of elevated serum advanced glycation end products and exercise on intact and injured murine tendons.Connective tissue research · 2023Article
- Musculoskeletal complications in patients with diabetes mellitus.The Korean journal of internal medicine · 2022Review
- Causes of Shoulder Dysfunction in Diabetic Patients: A Review of Literature.International journal of environmental research and public health · 2022Review
- Age and Intrinsic Fitness Affect the Female Rotator Cuff Tendon Tissue.Biomedicines · 2022Article
- Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products.PloS one · 2022Article
- Evaluation of Achilles Tendon in Patients with Diabetic Foot Ulcer by High-Frequency Ultrasound Combined with Real-Time Shear-Wave Elastography.Journal of healthcare engineering · 2022Article
- Mice with Type 2 Diabetes Present Significant Alterations in Their Tissue Biomechanical Properties and Histological Features.Biomedicines · 2021Article
- Understanding cellular and molecular mechanisms of pathogenesis of diabetic tendinopathy.World journal of stem cells · 2020Review
- Patients With Diabetes Mellitus Have a Higher Risk of Tendon Retear After Arthroscopic Rotator Cuff Repair: A Meta-analysis.Orthopaedic journal of sports medicine · 2020Review
- Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Biomechanical Testing of Murine Tendons.Journal of visualized experiments : JoVE · 2019Article
- Obesity/Type II Diabetes Promotes Function-limiting Changes in Murine Tendons that are not reversed by Restoring Normal Metabolic Function.Scientific reports · 2018Article
- What is the role of systemic conditions and options for manipulation of bone formation and bone resorption in rotator cuff tendon healing and repair?Techniques in shoulder & elbow surgery · 2017Article
- Compromised Neurotrophic and Angiogenic Regenerative Capability during Tendon Healing in a Rat Model of Type-II Diabetes.PloS one · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foot ulcers are a severe complication of diabetic patients resulting from nerve and tendon pathologic alterations. In diabetic patients the tendons are thicker, shorter and have increased stiffness. We examined C57BL/KsJ (BKS.Cg-Dock7(m) +/+ Lepr (db) /J) (db/db) mice tendons to determine whether they are an animal model for human diabetic tendon changes. We hypothesized that the Achilles tendons of db/db diabetic mice would be thicker, stiffer, fail at lower loads and stresses, and have degenerative changes compared to control mice. Biomechanical and histologic analyses of the Achilles tendons of 16 week old db/db and control male mice were performed. There was a significant increase in tendon diameter and significant decreases in maximum load, tensile stress, stiffness and elastic modulus in tendons from diabetic mice compared to controls. Mild degenerative and neutrophil infiltration was observed near the tendon insertions on the calcaneous in 25% of db/db mice. In summary, hyper-glycemia and obesity lead to severe changes in db/db mice will be a useful model to examine mechanisms for tendon alterations.
Indexed as
Identifiers
25489543PMC4241416W1972376010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.