ReviewAging and disease2014
The circadian timing system: a recent addition in the physiological mechanisms underlying pathological and aging processes.
Review in Aging and disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Multifaceted dynamics of circadian timing system influence aging and longevity.Biogerontology · 2025Review
- Association of age and night flight duration with sleep disorders among Chinese airline pilots.Frontiers in public health · 2023Article
- Circadian lifestyle determinants of immune checkpoint inhibitor efficacy.Frontiers in oncology · 2023Review
- Sleep Modulates Alcohol Toxicity inInternational journal of molecular sciences · 2022Article
- Effect of a dynamic lighting intervention on circadian rest-activity disturbances in cognitively impaired, older adults living in a nursing home: A proof-of-concept study.Neurobiology of sleep and circadian rhythms · 2021Article
- Deceptology in cancer and vaccine sciences: Seeds of immune destruction-mini electric shocks in mitochondria: Neuroplasticity-electrobiology of response profiles and increased induced diseases in four generations - A hypothesis.Clinical and translational medicine · 2020Review
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes.International journal of molecular sciences · 2018Review
- Aging and circadian dysfunction increase alcohol sensitivity and exacerbate mortality in Drosophila melanogaster.Experimental gerontology · 2017Article
- Disease relevant modifications of the methylome and transcriptome by particulate matter (PMEpigenetics · 2017Article
- Article
- How does healthy aging impact on the circadian clock?Journal of neural transmission (Vienna, Austria : 1996) · 2017Review
- Long Non-Coding RNA Profiling in a Non-Alcoholic Fatty Liver Disease Rodent Model: New Insight into Pathogenesis.International journal of molecular sciences · 2017Article
- Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?Clinical and translational medicine · 2016Article
- Carcinogenic effects of circadian disruption: an epigenetic viewpoint.Chinese journal of cancer · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Experimental findings and clinical observations have strengthened the association between physio-pathologic aspects of several diseases, as well as aging process, with the occurrence and control of circadian rhythms. The circadian system is composed by a principal pacemaker in the suprachiasmatic nucleus (SNC) which is in coordination with a number of peripheral circadian oscillators. Many pathological entities such as metabolic syndrome, cancer and cardiovascular events are strongly connected with a disruptive condition of the circadian cycle. Inadequate circadian physiology can be elicited by genetic defects (mutations in clock genes or circadian control genes) or physiological deficiencies (desynchronization between SCN and peripheral oscillators). In this review, we focus on the most recent experimental findings regarding molecular defects in the molecular circadian clock and the altered coordination in the circadian system that are related with clinical conditions such as metabolic diseases, cancer predisposition and physiological deficiencies associated to jet-lag and shiftwork schedules. Implications in the aging process will be also reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.