Evidence map›Paper›PMID 25489444›Full record

ArticleInternational journal of preventive medicine2014

Effect of Vitamin D Supplementation on C-reactive Protein in Patients with Nonalcoholic Fatty Liver.

Mahdi Foroughi, Zahra Maghsoudi, Reza Ghiasvand, Bijan Iraj, Gholamreza Askari

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In one paragraph

Article in International journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2021
    Pooled it
  3. Pooled it
  4. Vitamin D supplementation for chronic liver diseases in adults.The Cochrane database of systematic reviews · 2017
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mahdi ForoughiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Nutrition and Food Sciences, Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Zahra MaghsoudiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Nutrition and Food Sciences, Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Reza GhiasvandDepartment of Community Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Nutrition and Food Sciences, Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Community Nutrition, Metabolic Liver Diseases Research Center, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran.
Bijan IrajDepartment of Nutrition and Food Sciences, Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Gholamreza AskariDepartment of Community Nutrition, School of Nutrition and Food Sciences, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Nutrition and Food Sciences, Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the worldwide. It is associated with chronic disorders such as diabetes and heart diseases. Inflammation is one of the basic causes of metabolic diseases. Several studies have shown that Vitamin D can reduce inflammation. The purpose of this study was to investigate the effect of Vitamin D supplementation on inflammation in patients with NAFLD.

methodsThis study involved 60 NAFLD patients, divided equally into two intervention and placebo groups. During 10 weeks, patients in the intervention group receive Vitamin D (capsules containing 50,000 IU vitamin D), weekly. Vitamin D levels, C-reactive protein (CRP), triglyceride (TG), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured at the beginning and end of the study. Data were analyzed using analysis of covariance tests. Analyses were done using SPSS software (version 16) (SPSS Inc., Chicago, USA). P < 0.05 set as significant level.

resultsVitamin D supplementation resulted in an increase of serum 25(OH) D concentrations in inter group (P < 0.05) and intra-group (P < 0.05) in intervention group. At the end of the study, in the intervention group, TG and CRP reduced significantly compare with baseline (P < 0.05). A significant increase was seen in calcium serum in the intervention group in comparison with baseline (P < 0.05) and compared with the placebo group (P < 0.05).

conclusionsVitamin D supplementation had no effect on CRP and other variables in the intervention group compared with the placebo group. Further studies with strong design and more sample must conduct to demonstrate the effect of Vitamin D supplementation on inflammation in patients with NAFLD.

Indexed as

Inflammationnonalcoholic fatty livervitamin D

Identifiers

PMID25489444
PMCPMC4258669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.