Evidence map›Paper›PMID 25489015›Full record

ArticlePediatrics2015

Influenza-related hospitalization and ED visits in children less than 5 years: 2000-2011.

Astride Jules, Carlos G Grijalva, Yuwei Zhu, H Keipp Talbot, John V Williams, Katherine A Poehling, Sandra S Chaves, Kathryn M Edwards, William Schaffner, David K Shay and 1 more

Abstract read
In one paragraph

Article in Pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Antiviral Use Among Children Hospitalized With Laboratory-Confirmed Influenza Illness: A Prospective, Multicenter Surveillance Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Viral Kinetics and Resistance Development in Children Treated with Neuraminidase Inhibitors: The Influenza Resistance Information Study (IRIS).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Oseltamivir Treatment of Influenza in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
    Article
  15. Article
  16. Enterovirus D68 Infection Among Children With Medically Attended Acute Respiratory Illness, Cincinnati, Ohio, July-October 2014.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017
    Article
  17. Review
  18. Review
  19. Prevalence, codetection and seasonal distribution of upper airway viruses and bacteria in children with acute respiratory illnesses with cough as a symptom.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2016
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Astride JulesDepartments of Health Policy.
Carlos G GrijalvaDepartments of Health Policy.
Yuwei ZhuBiostatistics.
H Keipp TalbotMedicine.
John V WilliamsPediatrics, and Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee;
Katherine A PoehlingDepartments of Pediatrics and Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina; and.
Sandra S ChavesInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Kathryn M EdwardsPediatrics, and.
William SchaffnerDepartments of Health Policy.
David K ShayInfluenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Marie R GriffinDepartments of Health Policy, Medicine, marie.griffin@vanderbilt.edu.

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Annual Estimates of Influenza Vaccine Effectiveness: Davidson County, TNU18IP000184 · IP · VANDERBILT UNIVERSITY · PI GRIFFIN, MARIE R. · 2008 to 2010
$3.9M
Enhanced Surveillance-Newly Vaccine Preventable DiseasesU01IP000017 · IP · UNIVERSITY OF ROCHESTER · PI SZILAGYI, PETER G · 2004 to 2010
$3.8M
Enhanced Surveillance: New Vaccine Preventable DiseasesU01IP000022 · IP · VANDERBILT UNIVERSITY · PI EDWARDS, KATHRYN MARGARET · 2004 to 2010
$3.6M
The Movement of Influenza Virus In Human PopulationR01AI079226 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI POEHLING, KATHERINE A · 2009 to 2013
$3.3M
Enhanced Surveillance for New Vaccine Preventable DiseasesU01IP000147 · IP · CINCINNATI CHILDRENS HOSP MED CTR · PI STAAT, MARY A · 2007 to 2010
$2.8M
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NCIRD CDC HHS U01 IP000017NCIRD CDC HHS U01/IP000017NCIRD CDC HHS U01 IP000022NCIRD CDC HHS U01/IP000022NCIRD CDC HHS U01 IP000147NCIRD CDC HHS U01/IP000147NCIRD CDC HHS U01 IP000184NCIRD CDC HHS U18 IP000184NIAID NIH HHS R01 AI079226PHS HHS U38/CCU217969PHS HHS U38/CCU417958PHS HHS U38/CCU522352
6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn the United States, recommendations for annual influenza vaccination gradually expanded from 2004 to 2008, to include all children aged ≥6 months. The effects of these policies on vaccine uptake and influenza-associated health care encounters are unclear. The objectives of the study were to examine the annual incidence of influenza-related health care encounters and vaccine uptake among children age 6 to 59 months from 2000-2001 through 2010-2011 in Davidson County, TN.

methodsWe estimated the proportion of laboratory-confirmed influenza-related hospitalizations and emergency department (ED) visits by enrolling and testing children with acute respiratory illness or fever. We estimated influenza-related health care encounters by multiplying these proportions by the number of acute respiratory illness/fever hospitalizations and ED visits for county residents. We assessed temporal trends in vaccination coverage, and influenza-associated hospitalizations and ED visit rates.

resultsThe proportion of fully vaccinated children increased from 6% in 2000-2001 to 38% in 2010-2011 (P < .05). Influenza-related hospitalizations ranged from 1.9 to 16.0 per 10 000 children (median 4.5) per year. Influenza-related ED visits ranged from 89 to 620 per 10 000 children (median 143) per year. Significant decreases in hospitalizations (P < .05) and increases in ED visits (P < .05) over time were not clearly related to vaccination trends. Influenza-related encounters were greater when influenza A(H3N2) circulated than during other years with median rates of 8.2 vs 3.2 hospitalizations and 307 vs 143 ED visits per 10 000 children, respectively.

conclusionsInfluenza vaccination increased over time; however, the proportion of fully vaccinated children remained <50%. Influenza was associated with a substantial illness burden particularly when influenza A(H3N2) predominated.

Indexed as

Influenza A Virus, H3N2 SubtypeChild, PreschoolEmergenciesEmergency Service, HospitalFemaleHospitalizationHumansIncidenceInfantInfluenza, HumanInfluenza VaccinesMaleSeasonsTime FactorsVaccinationInfluenza Vaccineshospitalizationinfluenzarateratiovaccination coverage

Identifiers

PMID25489015
PMCPMC4279064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.