ArticleBritish journal of sports medicine2015
Lipids, adiposity and tendinopathy: is there a mechanistic link? Critical review.
Article in British journal of sports medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Clinical risk factors for Achilles tendinopathy: a systematic review.British journal of sports medicine · 2019Pooled it
- The association between body fat and musculoskeletal pain: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2018Pooled it
- Adolescent health behaviors, family socioeconomic status and health as risk factors for tendon ruptures in adulthood: a longitudinal study.BMC musculoskeletal disorders · 2025Article
- Normative Knee Range of Motion for Children.Life (Basel, Switzerland) · 2025Article
- Metabolic Risk Factors Relate to Worse Tendon Health in Individuals With Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Effects of Autologous Tenocyte Injection for Overuse and Degenerative Tendinopathies: A Systematic Review.Journal of functional morphology and kinesiology · 2025Review
- Increased adiposity and impaired sleep are associated with severity of greater trochanteric pain syndrome: a cross-sectional study.Frontiers in medicine · 2025Article
- Tendon Tissue Engineering: Pathophysiological Mechanism and Bioengineering Therapy of Tendinopathy.International journal of nanomedicine · 2025Review
- Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies.Mediators of inflammation · 2024Article
- Lipids, lipid-lowering drugs and lateral epicondylitis of the humerus: a drug-targeted Mendelian randomization study.Frontiers in genetics · 2024Article
- Hyperlipidemia Induced Pathological Changes with no Effect in Biomechanical Properties in the Achilles Tendon of Young Swine.Journal of orthopaedics and sports medicine · 2024Article
- Exposure to oxLDL impairs TGF-β activity in human tendon cells.BMC musculoskeletal disorders · 2023Article
- Creating an Optimal In Vivo Environment to Enhance Outcomes Using Cell Therapy to Repair/Regenerate Injured Tissues of the Musculoskeletal System.Biomedicines · 2022Review
- A high-fat diet has negative effects on tendon resident cells in an in vivo rat model.International orthopaedics · 2022Article
- Rotator Cuff Lesion and Obesity: A Demographic and Metabolic Evaluation.Revista brasileira de ortopedia · 2022Article
- Combined extracorporeal shockwave therapy and exercise for the treatment of tendinopathy: A narrative review.Sports medicine and health science · 2022Review
- Biomechanics and lower limb function are altered in athletes and runners with achilles tendinopathy compared with healthy controls: A systematic review.Frontiers in sports and active living · 2022Review
- Patellar Tendon Shear Wave Velocity Is Higher and has Different Regional Patterns in Elite Competitive Alpine Skiers than in Healthy Controls.Frontiers in bioengineering and biotechnology · 2022Article
- Inflammatory mechanisms linking obesity and tendinopathy.Journal of orthopaedic translation · 2021Review
- Tendinopathy.Nature reviews. Disease primers · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Being overweight or obese is associated with an elevated risk of tendon pathology. However, for sportspeople the epidemiological data linking weight or adiposity on one hand, and risk of tendon pathology on the other, are less consistent. Indeed, the mechanistic links between diet, adiposity and tendon pathology remain largely unexamined. Recent studies have begun to examine the effects of dietary interventions on outcomes such as tendon biomechanics or pain. Oxidised low-density lipoprotein has been shown to (A) accumulate in the tendon tissues of mice that eat a fatty diet and (B) induce a pathological phenotype in human tendon cells. This paper addresses the current debate: is excessive body mass index (causing increased load and strain on tendon tissue) per se the underlying mechanism? Or do local or systemic influences of fat on tendons predispose to tendon pathology? This narrative review argues that excessive blood lipids may be an important avenue for clinical investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.