Evidence map›Paper›PMID 25488688›Full record

ArticleThe Journal of allergy and clinical immunology2015

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.

Maria Pino-Yanes, Christopher R Gignoux, Joshua M Galanter, Albert M Levin, Catarina D Campbell, Celeste Eng, Scott Huntsman, Katherine K Nishimura, Pierre-Antoine Gourraud, Kiana Mohajeri and 40 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.

  1. Pooled it
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  13. From gene identifications to therapeutic targets for asthma: Focus on great potentials ofChinese medical journal pulmonary and critical care medicine · 2023
    Review
  14. Article
  15. Article
  16. Multiethnic genome-wide and HLA association study of total serum IgE level.The Journal of allergy and clinical immunology · 2021
    Article
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors at 20 institutions in 5 countries.

Maria Pino-YanesDepartment of Medicine, University of California, San Francisco, Calif; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. Electronic address: mdelpino@ull.edu.es.
Christopher R GignouxDepartment of Medicine, University of California, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif; Department of Genetics, Stanford University, Palo Alto, Calif.
Joshua M GalanterDepartment of Medicine, University of California, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Health System, Detroit, Mich.
Catarina D CampbellDepartment of Genome Sciences, University of Washington, Seattle, Wash.
Celeste EngDepartment of Medicine, University of California, San Francisco, Calif.
Scott HuntsmanDepartment of Medicine, University of California, San Francisco, Calif.
Katherine K NishimuraDepartment of Medicine, University of California, San Francisco, Calif.
Pierre-Antoine GourraudDepartment of Neurology, University of California, San Francisco, Calif.
Kiana MohajeriDepartment of Genome Sciences, University of Washington, Seattle, Wash.
Brian J O'RoakDepartment of Genome Sciences, University of Washington, Seattle, Wash; Molecular & Medical Genetics Department, Oregon Health and Science University, Portland, Ore.
Donglei HuDepartment of Medicine, University of California, San Francisco, Calif.
Rasika A MathiasDivision of Allergy & Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, Md.
Elizabeth A NguyenDepartment of Medicine, University of California, San Francisco, Calif.
Lindsey A RothDepartment of Medicine, University of California, San Francisco, Calif.
Badri PadhukasahasramCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Mich.
Andres Moreno-EstradaDepartment of Genetics, Stanford University, Palo Alto, Calif.
Karla SandovalDepartment of Genetics, Stanford University, Palo Alto, Calif.
Cheryl A WinklerBasic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, Md.
Fred LurmannSonoma Technology, Petaluma, Calif.
Adam DavisChildren's Hospital and Research Center Oakland, Oakland, Calif.
Harold J FarberDepartment of Pediatrics, Section of Pulmonology, Baylor College of Medicine and Texas Children's Hospital, Houston, Tex.
Kelley MeadeChildren's Hospital and Research Center Oakland, Oakland, Calif.
Pedro C AvilaDepartment of Medicine, Northwestern University, Chicago, Ill.
Denise SerebriskyPediatric Pulmonary Division, Jacobi Medical Center, Bronx, NY.
Rocio ChapelaInstituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico.
Jean G FordDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md.
Michael A LenoirBay Area Pediatrics, Oakland, Calif.
Shannon M ThyneDepartment of Pediatrics, University of California San Francisco, San Francisco General Hospital, San Francisco, Calif.
Emerita Brigino-BuenaventuraDepartment of Allergy and Immunology, Kaiser Permanente-Vallejo Medical Center, Vallejo, Calif.
Luisa N BorrellDepartment of Health Sciences, Graduate Program in Public Health, City University of New York, Bronx, NY.
William Rodriguez-CintronVeterans Caribbean Health Care System, San Juan, Puerto Rico.
Saunak SenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, Calif.
Rajesh KumarChildren's Memorial Hospital and the Feinberg School of Medicine, Northwestern University, Chicago, Ill.
Jose R Rodriguez-SantanaCentro de Neumología Pediátrica, San Juan, Puerto Rico.
Carlos D BustamanteDepartment of Genetics, Stanford University, Palo Alto, Calif.
Fernando D MartinezArizona Respiratory Center, University of Arizona, Tucson, Ariz; BIO5 Institute, University of Arizona, Tucson, Ariz.
Benjamin A RabyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Scott T WeissChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Dan L NicolaeDepartment of Human Genetics, University of Chicago, Chicago, Ill.
Carole OberDepartment of Human Genetics, University of Chicago, Chicago, Ill.
Deborah A MeyersCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Eugene R BleeckerCenter for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC.
Steven J MackChildren's Hospital Oakland Research Institute, Oakland, Calif.
Ryan D HernandezDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif.
Evan E EichlerDepartment of Genome Sciences, University of Washington, Seattle, Wash; Howard Hughes Medical Institute, Seattle, Wash.
Kathleen C BarnesDivision of Allergy & Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, Md.
L Keoki WilliamsCenter for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Mich; Department of Internal Medicine, Henry Ford Health System, Detroit, Mich.
Dara G TorgersonDepartment of Medicine, University of California, San Francisco, Calif.
Esteban G BurchardDepartment of Medicine, University of California, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif.
University of California, San Francisco · USHenry Ford Health System · USJohns Hopkins University · USStanford University · USBrigham and Women's Hospital · USUniversity of Chicago · USUniversity of Washington · USWake Forest University · USBaylor College of Medicine · USCentro de Neumologia Pediatrica · PRCity University of New York · USHoward Hughes Medical Institute · USInstituto Nacional de Enfermedades Respiratorias · MXJacobi Medical Center · USKaiser Permanente Vallejo Medical Center · USKIPP Bay Area Schools · USLeidos (United States) · USLurie Children's Hospital · USNorthwestern University · PHOregon Health & Science University · US

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
ZOLENDRONIC ACID IN CHILDREN W/ SEVERE OSTEOGENESIS IMPERFECTAM01RR000188 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI SHEARER, WILLIAM THOMAS · 1985 to 2011
$30.6M
New Approaches for Empowering Studies of Asthma in Populations of African DescentR01HL104608 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BARNES, KATHLEEN C, KENNY, EIMEAR ELIZABETH · 2011 to 2022
$23.1M
Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
The Genetic Epidemiology of Asthma in Costa RicaR37HL066289 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2015
$14.6M
Statistical GeneticsP01HL083069 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2007 to 2011
$12.2M
Clinical and Transtional Science InstituteKL2TR000143 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$11.9M
Regulation and expression of HLA-G in asthmatic airwaysU19AI095230 · NIAID · UNIVERSITY OF CHICAGO · PI OBER, CAROLE · 2011 to 2016
$10.5M
The Airway Functional Genomics of Bronchodilator Drug Response in Minority Children with AsthmaR01HL117004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AHITUV, NADAV, SEIBOLD, MAX A · 2013 to 2022
$9.3M
CLINICAL, PHARMACOLOGY, DRUG ACTION &PHARMACOKINETICST32GM007546 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Radojka Savic · 1985 to 2026
$8.9M
Genetics of Renal Disease in African AmericansZIABC010022 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WINKLER, CHERYL · 2009 to 2022
$8.9M
The Asthma BioRepository for Integrative Genomics ResearchRC2HL101543 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI RABY, BENJAMIN ALEXANDER, WEISS, SCOTT T · 2009 to 2010
$8.3M
NCATS NIH HHS KL2 TR000143NCATS NIH HHS KL2TR000143NCATS NIH HHS UL1 TR000430NCRR NIH HHS M01 RR000188NCRR NIH HHS M01-RR00188NHLBI NIH HHS HL004464NHLBI NIH HHS HL066289NHLBI NIH HHS HL075419NHLBI NIH HHS HL078885NHLBI NIH HHS HL083069NHLBI NIH HHS HL087680NHLBI NIH HHS HL088133NHLBI NIH HHS HL093023NHLBI NIH HHS HL101543NHLBI NIH HHS HL101651NHLBI NIH HHS HL104608NHLBI NIH HHS HL111636NHLBI NIH HHS HL117004NHLBI NIH HHS HL65899NHLBI NIH HHS K23 HL004464NHLBI NIH HHS K23 HL093023NHLBI NIH HHS K23 HL111636NHLBI NIH HHS P01 HL083069NHLBI NIH HHS R01 HL066289NHLBI NIH HHS R01 HL078885NHLBI NIH HHS R01 HL087680NHLBI NIH HHS R01 HL088133NHLBI NIH HHS R01 HL104608NHLBI NIH HHS R01 HL117004NHLBI NIH HHS R37 HL066289NHLBI NIH HHS RC2 HL101543NHLBI NIH HHS RC2 HL101651NHLBI NIH HHS U01 HL065899NHLBI NIH HHS U01 HL075419NIAID NIH HHS AI061774NIAID NIH HHS AI079139NIAID NIH HHS R01 AI061774NIAID NIH HHS R01 AI079139NIAID NIH HHS U19 AI095230NIEHS NIH HHS ES015794NIEHS NIH HHS R01 ES015794NIGMS NIH HHS GM007175NIGMS NIH HHS GM007546NIGMS NIH HHS T32 GM007175NIGMS NIH HHS T32 GM007546NIMHD NIH HHS MD006902NIMHD NIH HHS P60 MD006902
6 · The paper itself

Abstract

backgroundIgE is a key mediator of allergic inflammation, and its levels are frequently increased in patients with allergic disorders.

objectiveWe sought to identify genetic variants associated with IgE levels in Latinos.

methodsWe performed a genome-wide association study and admixture mapping of total IgE levels in 3334 Latinos from the Genes-environments & Admixture in Latino Americans (GALA II) study. Replication was evaluated in 454 Latinos, 1564 European Americans, and 3187 African Americans from independent studies.

resultsWe confirmed associations of 6 genes identified by means of previous genome-wide association studies and identified a novel genome-wide significant association of a polymorphism in the zinc finger protein 365 gene (ZNF365) with total IgE levels (rs200076616, P = 2.3 × 10(-8)). We next identified 4 admixture mapping peaks (6p21.32-p22.1, 13p22-31, 14q23.2, and 22q13.1) at which local African, European, and/or Native American ancestry was significantly associated with IgE levels. The most significant peak was 6p21.32-p22.1, where Native American ancestry was associated with lower IgE levels (P = 4.95 × 10(-8)). All but 22q13.1 were replicated in an independent sample of Latinos, and 2 of the peaks were replicated in African Americans (6p21.32-p22.1 and 14q23.2). Fine mapping of 6p21.32-p22.1 identified 6 genome-wide significant single nucleotide polymorphisms in Latinos, 2 of which replicated in European Americans. Another single nucleotide polymorphism was peak-wide significant within 14q23.2 in African Americans (rs1741099, P = 3.7 × 10(-6)) and replicated in non-African American samples (P = .011).

conclusionWe confirmed genetic associations at 6 genes and identified novel associations within ZNF365, HLA-DQA1, and 14q23.2. Our results highlight the importance of studying diverse multiethnic populations to uncover novel loci associated with total IgE levels.

Indexed as

Genetic LociGenome-Wide Association StudyGenotypeHispanic or LatinoPolymorphism, Single NucleotideAdolescentAdultBlack or African AmericanChildChromosome MappingChromosomes, Human, Pair 14DNA-Binding ProteinsFemaleGenome, HumanHLA-DQ alpha-ChainsHumansDNA-Binding ProteinsHLA-DQA1 antigenHLA-DQ alpha-ChainsImmunoglobulin ETranscription FactorsZNF365 protein, humanadmixture mappingallergyasthmagenome-wide association studyHispanicsIgELatinosminority populationsnext-generation sequencing

Identifiers

PMID25488688
PMCPMC4458233
OpenAlexW2076794521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.