ArticlePsychological medicine2015
Polygenic risk, stressful life events and depressive symptoms in older adults: a polygenic score analysis.
Article in Psychological medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
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Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review.Translational psychiatry · 2026Pooled it
- Investigating Relationships Between Genetic Risk, Childhood Maltreatment, and Eating Disorders in Women.Biological psychiatry global open science · 2026Article
- Joint Effects of Adverse Childhood Experiences and Genetic Burden of Depression on Multiple Depressive Symptoms.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- The long reach of childhood income inequality: a multinational twin study of gene-environment interplay on adult depressive symptoms.Psychological medicine · 2026Article
- Genetic susceptibility to depressive symptoms in middle-aged to older Americans: time-varying effects and effect modification by early psychosocial factors.Social psychiatry and psychiatric epidemiology · 2026Article
- Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up.Molecular psychiatry · 2026Article
- What machine learning teaches us about depression prediction across the life course: An exploratory comparison of predictive models.SSM - population health · 2025Article
- Intergenerational continuity of depressive symptoms: genetic and environmental pathways.Psychological medicine · 2025Article
- Patterns of stressful life events and polygenic scores for five mental disorders and neuroticism among adults with depression.Molecular psychiatry · 2024Article
- Divorce, genetic risk, and suicidal thoughts and behaviors in a sample with recurrent major depressive disorder.Journal of affective disorders · 2024Article
- Variety in Pleasant Activities is Associated with Improved Mental Health: Evidence from Two National Samples of U.S. Adults.Affective science · 2024Article
- The role of substance use disorders in the transition from suicide attempt to suicide death: a record linkage study of a Swedish cohort.Psychological medicine · 2024Article
- Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period.Genes, brain, and behavior · 2023Article
- Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Psychological medicine · 2023Observational
- Article
- Life-course inequalities in intrinsic capacity and healthy ageing, China.Bulletin of the World Health Organization · 2023Article
- Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes.Scientific reports · 2023Article
- Polygenic Risk and Social Support in Predicting Depression Under Stress.The American journal of psychiatry · 2023Article
- Stress-related exposures amplify the effects of genetic susceptibility on depression and anxiety.Translational psychiatry · 2023Article
- The relationship of adverse childhood experiences, hair cortisol, C-reactive protein, and polygenic susceptibility with older adults' psychological distress during the COVID-19 pandemic.Molecular psychiatry · 2022Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors.
Funding
Abstract
backgroundPrevious studies suggest that the relationship between genetic risk and depression may be moderated by stressful life events (SLEs). The goal of this study was to assess whether SLEs moderate the association between polygenic risk of major depressive disorder (MDD) and depressive symptoms in older adults.
methodWe used logistic and negative binomial regressions to assess the associations between polygenic risk, SLEs and depressive symptoms in a sample of 8761 participants from the Health and Retirement Study. Polygenic scores were derived from the Psychiatric Genomics Consortium genome-wide association study of MDD. SLEs were operationalized as a dichotomous variable indicating whether participants had experienced at least one stressful event during the previous 2 years. Depressive symptoms were measured using an eight-item Center for Epidemiologic Studies Depression Scale subscale and operationalized as both a dichotomous and a count variable.
resultsThe odds of reporting four or more depressive symptoms were over twice as high among individuals who experienced at least one SLE (odds ratio 2.19, 95% confidence interval 1.86-2.58). Polygenic scores were significantly associated with depressive symptoms (β = 0.21, p ⩽ 0.0001), although the variance explained was modest (pseudo r 2 = 0.0095). None of the interaction terms for polygenic scores and SLEs was statistically significant.
conclusionsPolygenic risk and SLEs are robust, independent predictors of depressive symptoms in older adults. Consistent with an additive model, we found no evidence that SLEs moderated the association between common variant polygenic risk and depressive symptoms.
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