Evidence map›Paper›PMID 25488341›Full record

ArticleHead & neck2016

Oropharyngeal cancer as a driver of racial outcome disparities in squamous cell carcinoma of the head and neck: 10-year experience at the University of Maryland Greenebaum Cancer Center.

Dan P Zandberg, Sandy Liu, Olga Goloubeva, Robert Ord, Scott E Strome, Mohan Suntharalingam, Rodney Taylor, Robert E Morales, Jeffrey S Wolf, Ann Zimrin and 3 more

Open access · greenAbstract read
In one paragraph

Article in Head & neck, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Review
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  4. Article
  5. Racioethnic disparities in comorbidities and outcomes following head and neck oncologic surgery.World journal of otorhinolaryngology - head and neck surgery · 2025
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  18. Head and neck cancer prevention: from primary prevention to impact of clinicians on reducing burden.Annals of oncology : official journal of the European Society for Medical Oncology · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Dan P ZandbergDepartment of Medicine, Division of Medical Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Sandy LiuDepartment of Pathology, University of Maryland School of Medicine, Baltimore, Maryland.
Olga GoloubevaUniversity of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland.
Robert OrdUniversity of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland.
Scott E StromeDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Mohan SuntharalingamDepartment of Radiation Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Rodney TaylorDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Robert E MoralesDepartment of Radiology, University of Maryland School of Medicine, Baltimore, Maryland.
Jeffrey S WolfDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
Ann ZimrinDepartment of Medicine, Division of Medical Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
Joshua E LubekUniversity of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland.
Lisa M SchumakerUniversity of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, Maryland.
Kevin J CullenDepartment of Medicine, Division of Medical Oncology, University of Maryland School of Medicine, Baltimore, Maryland.
University of Maryland, Baltimore · USUniversity of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer CenterUniversity of Maryland Medical Center · US

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI Vu H. Duong · 2008 to 2026
$51.0M
CLINICAL ONCOLOGY RESEARCH CAREER DEVELOPMENT PROGRAMK12CA076903 · NCI · GEORGETOWN UNIVERSITY · PI CULLEN, KEVIN J · 1997 to 2002
$1.0M
NCI NIH HHS K12 CA076903NCI NIH HHS P30 CA134274
6 · The paper itself

Abstract

backgroundRacial outcome disparities have been observed in head and neck squamous cell carcinoma (HNSCC) with diminished survival for black patients compared with white patients.

methodsWe retrospectively analyzed 1318 patients with primary HNSCC treated at the University of Maryland Greenebaum Cancer Center (UMGCC) from 2000 to 2010.

resultsOf all the patients, 65.9% were white, 30.7% were black, and 3.3% were of other races. Black patients were less likely to present with oral cavity cancer, and more likely to present with laryngeal or hypopharyngeal cancers. White patients were more likely to have early stage disease, especially in the oral cavity. Black race was independently associated with worse overall survival (OS) in the entire cohort. Black patients had a significantly worse OS among oral cavity and oropharyngeal cancers, with the largest disparity in oropharyngeal cancer. However, in multivariate analysis, race was only still significant in oropharyngeal cancer.

conclusionWe observed differences by race in distribution of disease site, stage, and OS. Survival disparity in the entire cohort was driven mostly by differences among oropharyngeal cancer.

Indexed as

AdultAgedAged, 80 and overBlack or African AmericanCarcinoma, Squamous CellFemaleHead and Neck NeoplasmsHealth Status DisparitiesHumansMaleMarylandMiddle AgedOropharyngeal NeoplasmsRacial GroupsRetrospective StudiesSquamous Cell Carcinoma of Head and Neckdisparityhead and neck squamous cell carcinoma (HNSCC)oropharyngealracesurvival

Identifiers

PMID25488341
PMCPMC4461547
OpenAlexW2147529290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.