Observational studyInternational journal of clinical pharmacy2015
Adverse drug reaction-related hospitalisations among patients with heart failure at two hospitals in the United Arab Emirates.
Observational study in International journal of clinical pharmacy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Prevalence and factors associated with adverse drug reactions among heart failure patients hospitalized at Mbarara Regional Referral Hospital, Uganda.BMC cardiovascular disorders · 2022Observational
- Clinically significant drug interactions between antiretroviral and co-prescribed drugs in HIV infected patients: retrospective cohort study.Medicine and pharmacy reports · 2022Article
- Ten-year trends in adverse drug reaction-related hospitalizations among people with dementia.Therapeutic advances in drug safety · 2022Article
- Observational
- Adverse drug reactions to anticoagulants in Spain: analysis of the Spanish National Hospital Discharge Data (2010-2013).BMJ open · 2017Article
- Knowledge, Beliefs and Behaviours Regarding the Adverse Effects of Medicines in an Omani Population: Cross-sectional survey.Sultan Qaboos University medical journal · 2015Article
- Drug-drug Interaction-related Uncontrolled Glycemia.Journal of pharmacy & bioallied sciencesArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the adverse drug reaction (ADR) related admissions among heart failure (HF) patients.
objectiveThe aim of this study was to determine the rate, factors, and medications associated with ADR-related hospitalisations among HF patients.
settingTwo government hospitals in Dubai, United Arab Emirates.
methodsThis was a prospective, observational study. Consecutive adult HF patients who were admitted between December 2011 and November 2012 to the cardiology units were included in this study. The circumstances of their admission were analysed.
main outcome measuresADRs-related admissions of HF patients to cardiology units were identified and further assessed for their nature, causality, and preventability.
resultsOf 511 admissions, 34 were due to ADR-related hospitalisation (6.65, 95 % confidence interval 4.8-8.5 %). Number of medications taken by HF patients was the only predictors of ADR-related hospitalisations, where higher number of medications was associated with the odd ratio of 1.11 (95 % CI, 1.03-1.20, P = 0.005). More than one-third of ADR-related hospitalisations (35 %) were preventable The most frequent drugs causing ADR-related hospitalisation were diuretics (32 %), followed by non-steroidal anti-inflammatory drugs (15 %), thiazolidinediones (9 %), anticoagulants (9 %), antiplatelets (6 %), and aldosterone blockers (6 %).
conclusionADR-related hospitalisations account for 6.7 % of admissions of HF patients to cardiac units, one-third of which are preventable. Number of medications taken by HF patients is the only predictors of ADR-related hospitalisations. Diuretic induced volume depletion, and sodium and water retention caused by thiazolidinediones and NSAIDs medications are the major causes of ADR-related hospitalisations of HF patients.
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