Evidence map›Paper›PMID 25488302›Full record

ArticleJournal of bacteriology2015

The Salmonella type III secretion system virulence effector forms a new hexameric chaperone assembly for export of effector/chaperone complexes.

Chi-Lin Tsai, Brianne J Burkinshaw, Natalie C J Strynadka, John A Tainer

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  5. Article
  6. Methods to Illuminate the Role ofFrontiers in cellular and infection microbiology · 2017
    Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Chi-Lin TsaiLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.ORCID http://orcid.org/0000-0002-0365-2405
Brianne J BurkinshawDepartment of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Natalie C J StrynadkaDepartment of Biochemistry and Molecular Biology and Center for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada ncjs@mail.ubc.ca JATainer@lbl.gov.
John A TainerLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA ncjs@mail.ubc.ca JATainer@lbl.gov.

Funding

MINOS (Macromolecular Insights on Nucleic acids Optimized by Scattering)R01GM105404 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI TAINER, JOHN A. · 2012 to 2015
$2.1M
Canadian Institutes of Health ResearchNIGMS NIH HHS R01 GM105404NIGMS NIH HHS R01GM105404
6 · The paper itself

Abstract

Bacteria hijack eukaryotic cells by injecting virulence effectors into host cytosol with a type III secretion system (T3SS). Effectors are targeted with their cognate chaperones to hexameric T3SS ATPase at the bacterial membrane's cytosolic face. In this issue of the Journal of Bacteriology, Roblin et al. (P. Roblin, F. Dewitte, V. Villeret, E. G. Biondi, and C. Bompard, J Bacteriol 197:688-698, 2015, http://dx.doi.org/10.1128/JB.02294-14) show that the T3SS chaperone SigE of Salmonella can form hexameric rings rather than dimers when bound to its cognate effector, SopB, implying a novel multimeric association for chaperone/effector complexes with their ATPase.

Indexed as

Bacterial ProteinsMolecular ChaperonesSalmonella typhimuriumSigma FactorBacterial ProteinsMolecular ChaperonessigE protein, BacteriaSigma FactorSopB protein, Bacteria

Identifiers

PMID25488302
PMCPMC4334186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.