ArticleChemphyschem : a European journal of chemical physics and physical chemistry2015
Improved sensitivity for imaging spin trapped hydroxyl radical at 250 MHz.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Direct Measurement and Imaging of Redox Status with Electron Paramagnetic Resonance.Antioxidants & redox signaling · 2024Article
- Rapid scan EPR: Automated digital resonator control for low-latency data acquisition.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022Article
- Fighting Antibiotic-Resistant Bacterial Infections by Surface Biofunctionalization of 3D-Printed Porous Titanium Implants with Reduced Graphene Oxide and Silver Nanoparticles.International journal of molecular sciences · 2022Article
- Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques.Pharmaceutics · 2021Review
- Rapid Scan EPR Oxygen Imaging in Photoactivated Resin Used for Stereolithographic 3D Printing.3D printing and additive manufacturing · 2021Article
- EPR Everywhere.Applied magnetic resonance · 2021Review
- Development of a fast-scan EPR imaging system for highly accelerated free radical imaging.Magnetic resonance in medicine · 2019Article
- A combined positron emission tomography (PET)-electron paramagnetic resonance imaging (EPRI) system: initial evaluation of a prototype scanner.Physics in medicine and biology · 2018Article
- Full cycle rapid scan EPR deconvolution algorithm.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Article
- Rapid-scan EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017Review
- Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo.Journal of visualized experiments : JoVE · 2016Article
- Rapid scan electron paramagnetic resonance at 1.0 GHz of defect centers in γ-irradiated organic solids.Radiation measurements · 2016Article
- Imaging disulfide dinitroxides at 250 MHz to monitor thiol redox status.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2015Article
- Rapid-Scan EPR of Nitroxide Spin Labels and Semiquinones.Methods in enzymology · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Radicals, including hydroxyl, superoxide, and nitric oxide, play key signaling roles in vivo. Reaction of these free radicals with a spin trap affords more stable paramagnetic nitroxides, but concentrations in vivo still are so low that detection by electron paramagnetic resonance (EPR) is challenging. Three innovative enabling technologies have been combined to substantially improve sensitivity for imaging spin-trapped radicals at 250 MHz. 1) Spin-trapped adducts of BMPO have lifetimes that are long enough to make imaging by EPR at 250 MHz feasible. 2) The signal-to-noise ratio of rapid-scan EPR is substantially higher than for conventional continuous-wave EPR. 3) An improved algorithm permits image reconstruction with a spectral dimension that encompasses the full 50 G spectrum of the BMPO-OH spin adduct without requiring the wide sweeps that would be needed for filtered backprojection. A 2D spectral-spatial image is shown for a phantom containing ca. 5 μM BMPO-OH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.