ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2015
Risk factors for acute kidney injury in older adults with critical illness: a retrospective cohort study.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 5 of them syntheses that pooled it.
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Who cites it
107 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Incidence and risk factors of acute kidney injury in patients with polypharmacy: a systematic review and meta-analysis.International journal of clinical pharmacy · 2025Pooled it
- Incidence, severity, risk factors and outcomes of acute kidney injury in older adults: systematic review and meta-analysis.Journal of nephrology · 2022Pooled it
- Female sex reduces the risk of hospital-associated acute kidney injury: a meta-analysis.BMC nephrology · 2018Pooled it
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 : Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine.Intensive care medicine · 2017Pooled it
- Predicting acute kidney injury at hospital re-entry using high-dimensional electronic health record data.PloS one · 2018Trial
- Comorbidity phenotypes and the incidence and severity of acute kidney injury in older critically ill patients: a retrospective cohort study.BMC geriatrics · 2026Article
- A nomogram model for predicting acute kidney injury in critically ill patients with upper gastrointestinal bleeding: a study based on the MIMIC-IV database and external validation.BMC gastroenterology · 2026Article
- Review
- Pathological networks and multi-target interventions in sepsis-associated acute lung injury: from pathogen-host interactions to gut-lung axis regulation.Frontiers in immunology · 2026Review
- Comparison of kinetic and standard formulas for estimating glomerular filtration rate in acute kidney injury: implications for antibiotic dosing, a prospective study.European journal of clinical pharmacology · 2025Observational
- Sleep disorders and sleep medications as risk factors for dementia in kidney transplant recipients: A retrospective cohort study.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Kidneys on the Frontline: Nephrologists Tackling the Wilds of Acute Kidney Injury in Trauma Patients-From Pathophysiology to Early Biomarkers.Diagnostics (Basel, Switzerland) · 2025Review
- Sepsis criteria and kidney function: eliminating sex, age and economic status biases.Nature reviews. Nephrology · 2025Review
- Prognostic Value of Blood Urea Nitrogen to Albumin Ratio in Elderly Critically Ill Patients with Acute Kidney Injury: A Retrospective Study.Medicina (Kaunas, Lithuania) · 2025Article
- COVID-19 associated acute kidney injury.Infectious diseases & immunity · 2025Review
- Long-Term Functional and Structural Renoprotection After Experimental Acute Kidney Injury in Subclinical Chronic Kidney Disease In Vivo.International journal of molecular sciences · 2025Article
- An effective multi-step feature selection framework for clinical outcome prediction using electronic medical records.BMC medical informatics and decision making · 2025Article
- Nutrition support for patients with renal dysfunction in the intensive care unit: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Review
- Acute Kidney Injury in Autoimmune-Mediated Rheumatic Diseases.Journal of clinical medicine research · 2025Review
47 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundRisk for acute kidney injury (AKI) in older adults has not been evaluated systematically. We sought to delineate the determinants of risk for AKI in older compared with younger adults. STUDY
designRetrospective analysis of patients hospitalized in July 2000 to September 2008. SETTING &
participantsWe identified all adult patients admitted to an intensive care unit (n=45,655) in a large tertiary-care university hospital system. We excluded patients receiving dialysis or a kidney transplant prior to hospital admission and patients with baseline creatinine levels ≥ 4mg/dL, liver transplantation, indeterminate AKI status, or unknown age, leaving 39,938 patients. PREDICTOR: We collected data for multiple susceptibilities and exposures, including age, sex, race, body mass, comorbid conditions, severity of illness, baseline kidney function, sepsis, and shock. OUTCOMES: We defined AKI according to KDIGO (Kidney Disease: Improving Global Outcomes) criteria. We examined susceptibilities and exposures across age strata for impact on the development of AKI. MEASUREMENTS: We calculated area under the receiver operating characteristic curve (AUC) for prediction of AKI across age groups.
results25,230 (63.2%) patients were 55 years or older. Overall, 25,120 (62.9%) patients developed AKI (69.2% aged ≥55 years). Examples of risk factors for AKI in the oldest age category (≥75 years) were drugs (vancomycin, aminoglycosides, and nonsteroidal anti-inflammatories), history of hypertension (OR, 1.13; 95% CI, 1.02-1.25), and sepsis (OR, 2.12; 95% CI, 1.68-2.67). Fewer variables remained predictive of AKI as age increased and the model for older patients was less predictive (P<0.001). For the age categories 18 to 54, 55 to 64, 65 to 74, and 75 years or older, AUCs were 0.744 (95% CI, 0.735-0.752), 0.714 (95% CI, 0.702-0.726), 0.706 (95% CI, 0.693-0.718), and 0.673 (95% CI, 0.661-0.685), respectively. LIMITATIONS: Analysis may not apply to non-intensive care unit patients.
conclusionsThe likelihood of developing AKI increases with age; however, the same variables are less predictive for AKI as age increases. Efforts to quantify risk for AKI may be more difficult in older adults.
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