SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2015
Role of vitamin C in prevention of complex regional pain syndrome after distal radius fractures: a meta-analysis.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- A meta-analysis of randomized clinical trials on the impact of oral vitamin C supplementation on first-year outcomes in orthopedic patients.Scientific reports · 2021Pooled it
- Pooled it
- Comparison of treatment outcomes between nonsurgical and surgical treatment of distal radius fracture in elderly: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2015Pooled it
- Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty.Drug design, development and therapy · 2025Trial
- Effect of perioperative single dose intravenous vitamin C on pain after total hip arthroplasty.Journal of orthopaedic surgery and research · 2024Trial
- Regional vitamin C in Bier block reduces the incidence of CRPS-1 following distal radius fracture surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Trial
- Review
- The Role of Vitamin C Supplementation in Total Knee Arthroplasty Outcomes: A Systematic Review of Randomized Controlled Trials.The archives of bone and joint surgery · 2026Review
- Ascorbic Acid Reduces the Blood Boss After Total Knee Arthroplasty: Insights From a Randomized Controlled Trial.Arthroplasty today · 2025Article
- Complex Regional Pain Syndrome after Distal Radius Fracture-Case Report and Mini Literature Review.Journal of clinical medicine · 2024Article
- From a Symptom-Based to a Mechanism-Based Pharmacotherapeutic Treatment in Complex Regional Pain Syndrome.Drugs · 2022Review
- Complex Regional Pain Syndrome: A Comprehensive Review.Pain and therapy · 2021Review
- Influence of vitamin C on the incidence of CRPS-I after subacromial shoulder surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2020Article
- Oxidative Stress Contributes to Fracture/Cast-Induced Inflammation and Pain in a Rat Model of Complex Regional Pain Syndrome.The journal of pain · 2018Article
- The best cited articles of the European Journal of Orthopaedic Surgery and Traumatology (EJOST): a bibliometric analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Article
- Complex Regional Pain Syndrome, Current Concepts and Treatment Options.Current pain and headache reports · 2018Review
- Do Orthopedic Trauma Surgeons Adhere to AAOS Guidelines when Treating Distal Radius Fractures?The Iowa orthopaedic journal · 2018Article
- The role of vitamin C in the treatment of pain: new insights.Journal of translational medicine · 2017Review
- Comparison of effects of seven treatment methods for distal radius fracture on minimizing complex regional pain syndrome.Archives of medical science : AMS · 2017Article
- Complex regional pain syndrome: a recent update.Burns & trauma · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComplex regional pain syndrome is a well-known complication after distal radius fracture with incidence ranging from 10.5 to 37 %. Some studies recommend the use of vitamin C to prevent complex regional pain syndrome. The objective of this meta-analysis was to evaluate the efficacy of vitamin C in prevention of CRPS.
methodsWe searched the PubMed, EMBASE and Cochrane library databases for randomized controlled trial (RCT) and comparative studies reporting use of vitamin C to prevent distal radius fracture. Dichotomous variable was presented as risk ratio with 95 % confidence intervals.
resultsWe obtained 220 articles from the database search. After the exclusion of duplicates, unrelated articles, letter to editor and editorials, we found four articles relevant to our topic. Meta-analysis of the CRPS incidence revealed that the incidence of CRPS was significantly lower in the vitamin C group [RD 0.41 (0.19-0.92), P = 0.03]. There was moderate to high heterogeneity in the studies included I (2) = 63 %).
conclusionsOur analysis showed a significant reduction in prevalence of CRPS with the use of vitamin C. Further high-quality RCTs with standard dosages and common diagnostic criteria are needed to be able to deliver solid conclusions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.