ArticleeLife2014
Dopamine drives Drosophila sechellia adaptation to its toxic host.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
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- Genomic Islands of Divergence Between Drosophila yakuba Subspecies are Predominantly Driven by Chromosomal Inversions and the Recombination Landscape.Molecular ecology · 2025Article
- Evolution of connectivity architecture in the Drosophila mushroom body.Nature communications · 2024Article
- Odor-regulated oviposition behavior in an ecological specialist.Nature communications · 2023Article
- Genetic variation in disease resistance in Drosophila spp. is mitigated in Drosophila sechellia by specialization to a toxic host.Scientific reports · 2023Article
- Low Endosymbiont Incidence in Drosophila Species Across Peninsula Thailand.Microbial ecology · 2023Article
- Taste adaptations associated with host specialization in the specialist Drosophila sechellia.The Journal of experimental biology · 2023Article
- Genomics analysis of Drosophila sechellia response to Morinda citrifolia fruit diet.G3 (Bethesda, Md.) · 2022Article
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- α-synuclein impairs autophagosome maturation through abnormal actin stabilization.PLoS genetics · 2021Article
- Comparative analysis of diet-associated responses in two rice planthopper species.BMC genomics · 2020Article
- Does Divergence in Habitat Breadth Associate with Species Differences in Decision Making inGenes · 2020Article
- A Continuum of Evolving De Novo Genes Drives Protein-Coding Novelty in Drosophila.Journal of molecular evolution · 2020Article
- Genomics Analysis of L-DOPA Exposure inG3 (Bethesda, Md.) · 2019Article
- Reproductive Capacity Evolves in Response to Ecology through Common Changes in Cell Number in Hawaiian Drosophila.Current biology : CB · 2019Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
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Abstract
Many insect species are host-obligate specialists. The evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing. We analyzed the tight association of Drosophila sechellia to its sole host, the fruit of Morinda citrifolia, which is toxic to other members of the melanogaster species group. Molecular polymorphisms in the dopamine regulatory protein Catsup cause infertility in D. sechellia due to maternal arrest of oogenesis. In its natural host, the fruit compensates for the impaired maternal dopamine metabolism with the precursor l-DOPA, resuming oogenesis and stimulating egg production. l-DOPA present in morinda additionally increases the size of D. sechellia eggs, what in turn enhances early fitness. We argue that the need of l-DOPA for successful reproduction has driven D. sechellia to become an M. citrifolia obligate specialist. This study illustrates how an insect's dopaminergic system can sustain ecological adaptations by modulating ontogenesis and development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.