Evidence map›Paper›PMID 25487834›Full record

ArticleMagma (New York, N.Y.)2015

Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.

Gregory Chang, Alexandra Hotca-Cho, Henry Rusinek, Stephen Honig, Artem Mikheev, Kenneth Egol, Ravinder R Regatte, Chamith S Rajapakse

Abstract read
In one paragraph

Article in Magma (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. MRI assessment of bone structure and microarchitecture.Journal of magnetic resonance imaging : JMRI · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gregory ChangDepartment of Radiology, Center for Biomedical Imaging, NYU Langone Medical Center, 660 First Avenue, Room 334, 3rd Floor, New York, NY, 10016, USA, Gregory.chang@nyumc.org.
Alexandra Hotca-Cho
Henry Rusinek
Stephen Honig
Artem Mikheev
Kenneth Egol
Ravinder R Regatte
Chamith S Rajapakse

Funding

MRI of Proximal Femur Microarchitecture as a Biomarker of Bone QualityR01AR066008 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2014 to 2018
$2.8M
Osteoarthritis: Identification of Novel Imaging Biomarkers via 23Na/1H MRI at 7 TK23AR059748 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHANG, GREGORY · 2011 to 2015
$663k
Computational Biomechanics for Prediction of Osteoporotic Vertebral Fracture RiskK25AR060283 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI RAJAPAKSE, CHAMITH SUDESH · 2011 to 2014
$491k
NIAMS NIH HHS K23 AR059748NIAMS NIH HHS K25 AR060283NIAMS NIH HHS R01 AR066008
6 · The paper itself

Abstract

introductionOsteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength.

methodsThis study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus.

resultsWithin-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively.

conclusionThe measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.

Indexed as

Elastic ModulusFemaleFemurFinite Element AnalysisHumansMaleMiddle AgedOsteoporosisReproducibility of Results

Identifiers

PMID25487834
PMCPMC4605426

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.