ArticlePediatric nephrology (Berlin, Germany)2015
Healthcare burden of venous thromboembolism in childhood chronic renal diseases.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Safety and clinical outcomes of antithrombotic therapy in children and young adults with kidney failure on dialysis: a 10-year single-center retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Case report: cerebral venous sinus thrombosis and pulmonary embolism as the initial presentation in a child with asymptomatic primary nephrotic syndrome.Frontiers in pediatrics · 2023Article
- Thrombosis in Chronic Kidney Disease in Children.Diagnostics (Basel, Switzerland) · 2022Article
- Venous Thromboembolism in Kidney Diseases and Genetic Predisposition.Kidney diseases (Basel, Switzerland) · 2022Review
- Nephrotic syndrome-associated hypercoagulopathy is alleviated by both pioglitazone and glucocorticoid which target two different nuclear receptors.Physiological reports · 2020Article
- Role of direct oral anticoagulants in patients with kidney disease.Kidney international · 2020Review
- Venous thromboembolism in chronic pediatric heart disease is associated with substantial health care burden and expenditures.Research and practice in thrombosis and haemostasis · 2019Article
- Association of infections and venous thromboembolism in hospitalized children with nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2019Article
- Prevalence and risk factors for venous thromboembolism in children with sickle cell disease: an administrative database study.Blood advances · 2018Article
- Epidemiology and Risk Assessment of Pediatric Venous Thromboembolism.Frontiers in pediatrics · 2017Review
- Association of serum albumin level and venous thromboembolic events in a large cohort of patients with nephrotic syndrome.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017Article
- Complications and 30-day Outcomes Associated With Venous Thromboembolism in the Pediatric Orthopaedic Surgical Population.The Journal of the American Academy of Orthopaedic Surgeons · 2016Article
- The emerging role of coagulation proteases in kidney disease.Nature reviews. Nephrology · 2016Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic renal diseases (CRD) are associated with approximately 5% of pediatric venous thromboembolism (VTE) cases, but the epidemiology of VTE in CRD is ill-defined.
methodsChildren (<18 years) with CRD were identified from MarketScan® Research databases. The VTE status of subjects with CRD who qualified for this study was ascertained during the 6 months following the initial diagnosis of CRD. Demographics, healthcare utilization, mortality, and co-morbid conditions were assessed.
resultsA total of 22,877 children with predefined CRD ICD-9-CM codes were identified between April 1, 2003 and June 30, 2012, among whom 0.55% had VTE. Our analysis revealed that in-hospital mortality was more likely in children with VTE than in those without VTE (11.9 vs. 0.9%, respectively; p < 0.0001). The usage of healthcare facilities, based on the number of inpatient admissions, length of stay, outpatient visits, and pharmaceutical claims, was also significantly higher in patients with VTE than in those without (p < 0.0001). Total mean healthcare expenditures for the 6-month follow-up period were 13-fold greater in the VTE group than in the group without VTE ($338,338 ± $544,045 vs. $25,171 ± $90,792; p < 0.0001). In a multivariate model, infection, hemodialysis, and trauma/surgery significantly increased the likelihood of VTE.
conclusionsVenous thromboembolism is rare in children with CRD, but it is associated with higher mortality and healthcare utilization when present. Among the children with CRD enrolled in our study, the likelihood of VTE was increased among those with co-morbid, non-renal chronic conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.