ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Ancient genomics.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Establishment and validation of a DIP panel for forensic ancestry inference and personal identification.Human genomics · 2025Article
- Insights into Treponema pallidum genomics from modern and ancient genomes using a novel mapping strategy.BMC biology · 2025Article
- A fresh perspective on infrared spectroscopy as a prescreening method for molecular and stable isotopes analyses on ancient human bones.Scientific reports · 2024Article
- Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases.Journal of clinical medicine · 2022Review
- Competitive mapping allows for the identification and exclusion of human DNA contamination in ancient faunal genomic datasets.BMC genomics · 2020Article
- A systematic investigation of human DNA preservation in medieval skeletons.Scientific reports · 2020Article
- Neanderthals as familiar strangers and the human spark: How the 'golden years' of Neanderthal research reopen the question of human uniqueness.History and philosophy of the life sciences · 2020Article
- The past, present and future of ancient bacterial DNA.Microbial genomics · 2020Review
- A likelihood method for estimating present-day human contamination in ancient male samples using low-depth X-chromosome data.Bioinformatics (Oxford, England) · 2020Article
- Population-level inferences from environmental DNA-Current status and future perspectives.Evolutionary applications · 2020Review
- Reconstructing the Complex Evolutionary History of the PapuasianFrontiers in plant science · 2020Article
- Unlocking the origins and biology of domestic animals using ancient DNA and paleogenomics.BMC biology · 2019Review
- Not a limitless resource: ethics and guidelines for destructive sampling of archaeofaunal remains.Royal Society open science · 2019Article
- Origin of the New World Plasmodium vivax: Facts and New Approaches.International microbiology : the official journal of the Spanish Society for Microbiology · 2019Article
- Ancient RNA from Late Pleistocene permafrost and historical canids shows tissue-specific transcriptome survival.PLoS biology · 2019Article
- Ancient DNA reveals the timing and persistence of organellar genetic bottlenecks over 3,000 years of sunflower domestication and improvement.Evolutionary applications · 2019Article
- snpAD: an ancient DNA genotype caller.Bioinformatics (Oxford, England) · 2018Article
- A new self-learning computational method for footprints of early human migration processes.Molecular genetics and genomics : MGG · 2018Article
- Quantifying and reducing spurious alignments for the analysis of ultra-short ancient DNA sequences.BMC biology · 2018Article
- A Post-pleistocene Calibrated Mutation Rate from Insect Museum Specimens.PLoS currents · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The past decade has witnessed a revolution in ancient DNA (aDNA) research. Although the field's focus was previously limited to mitochondrial DNA and a few nuclear markers, whole genome sequences from the deep past can now be retrieved. This breakthrough is tightly connected to the massive sequence throughput of next generation sequencing platforms and the ability to target short and degraded DNA molecules. Many ancient specimens previously unsuitable for DNA analyses because of extensive degradation can now successfully be used as source materials. Additionally, the analytical power obtained by increasing the number of sequence reads to billions effectively means that contamination issues that have haunted aDNA research for decades, particularly in human studies, can now be efficiently and confidently quantified. At present, whole genomes have been sequenced from ancient anatomically modern humans, archaic hominins, ancient pathogens and megafaunal species. Those have revealed important functional and phenotypic information, as well as unexpected adaptation, migration and admixture patterns. As such, the field of aDNA has entered the new era of genomics and has provided valuable information when testing specific hypotheses related to the past.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.