ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Twenty-five thousand years of fluctuating selection on leopard complex spotting and congenital night blindness in horses.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Genetic Footprints of Seasonal Fluctuating Selection: A Comparison With Established Selection Forms.Genome biology and evolution · 2026Article
- Article
- Estimating Temporally Variable Selection Intensity from Ancient DNA Data.Molecular biology and evolution · 2023Article
- Basal Reactivity Evaluated by Infrared Thermography in the "Caballo de Deporte Español" Horse Breed According to Its Coat Color.Animals : an open access journal from MDPI · 2022Article
- Ancient DNA shows domestic horses were introduced in the southern Caucasus and Anatolia during the Bronze Age.Science advances · 2020Article
- Decline of genetic diversity in ancient domestic stallions in Europe.Science advances · 2018Article
- Harnessing ancient genomes to study the history of human adaptation.Nature reviews. Genetics · 2017Review
- Human evolution: a tale from ancient genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Evolutionary Patterns and Processes: Lessons from Ancient DNA.Systematic biology · 2017Review
- Spotted phenotypes in horses lost attractiveness in the Middle Ages.Scientific reports · 2016Article
- Review
- Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes.Nature genetics · 2015Article
- Introduction. Ancient DNA: the first three decades.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
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Authors and funding
10 authors at 9 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leopard complex spotting is inherited by the incompletely dominant locus, LP, which also causes congenital stationary night blindness in homozygous horses. We investigated an associated single nucleotide polymorphism in the TRPM1 gene in 96 archaeological bones from 31 localities from Late Pleistocene (approx. 17 000 YBP) to medieval times. The first genetic evidence of LP spotting in Europe dates back to the Pleistocene. We tested for temporal changes in the LP associated allele frequency and estimated coefficients of selection by means of approximate Bayesian computation analyses. Our results show that at least some of the observed frequency changes are congruent with shifts in artificial selection pressure for the leopard complex spotting phenotype. In early domestic horses from Kirklareli-Kanligecit (Turkey) dating to 2700-2200 BC, a remarkably high number of leopard spotted horses (six of 10 individuals) was detected including one adult homozygote. However, LP seems to have largely disappeared during the late Bronze Age, suggesting selection against this phenotype in early domestic horses. During the Iron Age, LP reappeared, probably by reintroduction into the domestic gene pool from wild animals. This picture of alternating selective regimes might explain how genetic diversity was maintained in domestic animals despite selection for specific traits at different times.
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