ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015
Parallel detection of ancient pathogens via array-based DNA capture.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A minimal hybridization capture approach for the parallel enrichment and cost-effective detection of ancient human pathogens.iScience · 2026Article
- An Adagio for Viruses, Played Out on Ancient DNA.Genome biology and evolution · 2023Review
- A nontuberculous mycobacterium could solve the mystery of the lady from the Franciscan church in Basel, Switzerland.BMC biology · 2023Article
- Insights into health and disease from ancient biomolecules.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- The Recovery, Interpretation and Use of Ancient Pathogen Genomes.Current biology : CB · 2020Review
- Screening methods for detection of ancient Mycobacterium tuberculosis complex fingerprints in next-generation sequencing data derived from skeletal samples.GigaScience · 2019Article
- Ancient pathogen genomics as an emerging tool for infectious disease research.Nature reviews. Genetics · 2019Review
- Article
- The Role of aDNA in Understanding the Coevolutionary Patterns of Human Sexually Transmitted Infections.Genes · 2018Review
- Ancient oncogenesis, infection and human evolution.Evolutionary applications · 2017Review
- Review
- A Robust Framework for Microbial Archaeology.Annual review of genomics and human genetics · 2017Review
- Paleoproteomics of the Dental Pulp: The plague paradigm.PloS one · 2017Article
- Sequence capture by hybridization to explore modern and ancient genomic diversity in model and nonmodel organisms.Nucleic acids research · 2016Review
- Targeted capture in evolutionary and ecological genomics.Molecular ecology · 2016Review
- Targeted amplification for enhanced detection of biothreat agents by next-generation sequencing.BMC research notes · 2015Article
- Reconstructing ancient genomes and epigenomes.Nature reviews. Genetics · 2015Review
- Introduction. Ancient DNA: the first three decades.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA capture coupled with next generation sequencing is highly suitable for the study of ancient pathogens. Screening for pathogens can, however, be meticulous when assays are restricted to the enrichment of single organisms, which is common practice. Here, we report on an array-based DNA capture screening technique for the parallel detection of nearly 100 pathogens that could have potentially left behind molecular signatures in preserved ancient tissues. We demonstrate the sensitivity of our method through evaluation of its performance with a library known to harbour ancient Mycobacterium leprae DNA. This rapid and economical technique will be highly useful for the identification of historical diseases that are difficult to characterize based on archaeological information alone.
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