Evidence map›Paper›PMID 25487044›Full record

ArticleJournal of the International Neuropsychological Society : JINS2015

Executive Function in Children and Adolescents with Critical Cyanotic Congenital Heart Disease.

Adam R Cassidy, Matthew T White, David R DeMaso, Jane W Newburger, David C Bellinger

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03035552 (Randomized Controlled Trial to Improve Oral Feeding Outcomes in Infants With Complex Congenital Heart Disease Using Pacifier Activated Device-Training With Mother's Voice), which is not on this map. Cited by 103 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03035552 nacompletednot on this mapstarted 2016, after this paper: background citation

Randomized Controlled Trial to Improve Oral Feeding Outcomes in Infants With Complex Congenital Heart Disease Using Pacifier Activated Device-Training With Mother's Voice

TypeinterventionalSponsorNationwide Children's HospitalRan2016 to 2023Enrolled61ConditionsHeart Defects, CongenitalArmsPacifier activated music player
3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 1 synthesis or guideline pooled it, 231 citations in OpenAlex.

  1. Pooled it
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  16. Observational
  17. Cognitive disengagement syndrome and peer relationships of youth with critical congenital heart defects.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025
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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Adam R Cassidy1Department of Psychiatry,Boston Children's Hospital,Harvard Medical School,Boston,Massachusetts.
Matthew T White1Department of Psychiatry,Boston Children's Hospital,Harvard Medical School,Boston,Massachusetts.
David R DeMaso1Department of Psychiatry,Boston Children's Hospital,Harvard Medical School,Boston,Massachusetts.
Jane W Newburger2Department of Cardiology,Boston Children's Hospital,Harvard Medical School,Boston,Massachusetts.
David C Bellinger1Department of Psychiatry,Boston Children's Hospital,Harvard Medical School,Boston,Massachusetts.
Boston Children's Hospital · US

Funding

SSCOR in Pediatric Heart Development and DiseaseP50HL074734 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI COLLINS, TUCKER O · 2004 to 2008
$19.9M
WIRELESS CAPSULE ENDOSCOPY TO EVALUATE THE SMALL INTESTINE M01RR002172 · NCRR · CHILDREN'S HOSPITAL BOSTON · PI MANDELL, JAMES WILLIAM · 1985 to 2008
$16.0M
Outcomes in Adolescence after Repair of d-TGAR01HL077681 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 2004 to 2008
$3.1M
Brain Structure and Function in Adolescents after the Fontan OperationR01HL096825 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI NEWBURGER, JANE W., RIVKIN, MICHAEL JOHN · 2009 to 2012
$2.9M
INFANT HEART SURGERY: CNS SEQUELAE OF CIRCULATORY ARRESTR01HL041786 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI NEWBURGER, JANE W. · 1989 to 2001
$467k
NCRR NIH HHS M01 RR002172NCRR NIH HHS RR02172NHLBI NIH HHS HL096825NHLBI NIH HHS HL74734NHLBI NIH HHS HL77681NHLBI NIH HHS P50 HL074734NHLBI NIH HHS R01 HL077681NHLBI NIH HHS R01 HL096825
6 · The paper itself

Abstract

Children and adolescents with critical cyanotic congenital heart disease (CHD) are at risk for deficits in aspects of executive function (EF). The primary aim of this investigation was to compare EF outcomes in three groups of children/adolescents with severe CHD and controls (ages 10-19 years). Participants included 463 children/adolescents with CHD [dextro-transposition of the great arteries (TGA), n=139; tetralogy of Fallot (TOF), n=68; and, single-ventricle anatomy requiring Fontan procedure (SVF), n=145] and 111 controls, who underwent laboratory and informant-based evaluation of EF skills. Rates of EF impairment on D-KEFS measures were nearly twice as high for CHD groups (75-81%) than controls (43%). Distinct EF profiles were documented between CHD groups on D-KEFS tasks. Deficits in flexibility/problem-solving and verbally mediated EF skills were documented in all three CHD groups; visuo-spatially mediated EF abilities were impaired in TOF and SVF groups, but preserved in TGA. Parent, teacher, and self-report ratings on the BRIEF highlighted unique patterns of metacognitive and self-regulatory concerns across informants. CHD poses a serious threat to EF development. Greater severity of CHD is associated with worse EF outcomes. With increased understanding of the cognitive and self-regulatory vulnerabilities experienced by children and adolescents with CHD, it may be possible to identify risks early and provide individualized supports to promote optimal neurodevelopment.

Indexed as

AdolescentAnalysis of VarianceChildCognition DisordersExecutive FunctionFemaleHeart Defects, CongenitalHumansMaleNeuropsychological TestsPhotic StimulationSpace PerceptionSurveys and QuestionnairesYoung AdultBRIEF: Behavior Rating Inventory of Executive Function.CHD: congenital heart diseaseCongenital heart defectsD-KEFS: Delis-Kaplan Executive Function SystemExecutive functionFontan procedureHLHS: hypoplastic left heart syndromeSingle-ventricleSVF: single-ventricle cardiac conditions requiring Fontan procedureTetralogy of FallotTGA: dextro-transposition of the great arteriesTOF: tetralogy of FallotTransposition of great vessels

Identifiers

PMID25487044
PMCPMC4762262
OpenAlexW2138313967

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.