ArticleChannels (Austin, Tex.)2015
Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel.
Article in Channels (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Structural evidence that a lipid plug controls KNature communications · 2026Article
- Insights into the structure and modulation of human TWIK-2.Nature communications · 2026Article
- Studying the Effects of Dissolved Noble Gases and High Hydrostatic Pressure on the Spherical DOPC Bilayer Using Molecular Dynamic Simulations.Membranes · 2024Article
- Molecular Biophysics of Class A G Protein Coupled Receptors-Lipids Interactome at a Glance-Highlights from the ABiomolecules · 2023Review
- When is a hydrophobic gate not a hydrophobic gate?The Journal of general physiology · 2022Article
- Structural Basis for pH-gating of the KNature communications · 2022Article
- Interfacial Binding Sites for Cholesterol on Kir, Kv, KBiophysical journal · 2020Article
- Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P KThe Journal of biological chemistry · 2020Article
- Emerging Diversity in Lipid-Protein Interactions.Chemical reviews · 2019Review
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- A Database of Predicted Binding Sites for Cholesterol on Membrane Proteins, Deep in the Membrane.Biophysical journal · 2018Article
- Energetic differences between non-domain-swapped and domain-swapped chain connectivities in the K2P potassium channel TRAAK.RSC advances · 2018Article
- Halogenated Ether, Alcohol, and Alkane Anesthetics Activate TASK-3 Tandem Pore Potassium Channels Likely through a Common Mechanism.Molecular pharmacology · 2017Article
- Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel.Structure (London, England : 1993) · 2017Article
- Locomotion Behavior Is Affected by the GαGenetics · 2017Article
- Exploring the Dynamics of the TWIK-1 Channel.Biophysical journal · 2016Article
- Much more than a leak: structure and function of K₂p-channels.Pflugers Archiv : European journal of physiology · 2015Review
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Authors and funding
5 authors.
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Abstract
Several recent ion channel structures have revealed large side portals, or 'fenestrations' at the interface between their transmembrane helices that potentially expose the ion conduction pathway to the lipid core of the bilayer. In a recent study we demonstrated that functional activity of the TWIK-1 K2P channel is influenced by the presence of hydrophobic residues deep within the inner pore. These residues are located near the fenestrations in the TWIK-1 structure and promote dewetting of the pore by forming a hydrophobic barrier to ion conduction. During our previous MD simulations, lipid tails were observed to enter these fenestrations. In this addendum to that study, we investigate lipid contribution to the dewetting process. Our results demonstrate that lipid tails from both the upper and lower leaflets can occupy the fenestrations and partially penetrate into the pore. The lipid tails do not sterically occlude the pore, but there is an inverse correlation between the presence of water within the hydrophobic barrier and the number of lipids tails within the lining of the pore. However, dewetting still occurs in the absence of lipids tails, and pore hydration appears to be determined primarily by those side-chains lining the narrowest part of the pore cavity.
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