Evidence map›Paper›PMID 25486950›Full record

ReviewClinical lymphoma, myeloma & leukemia2014

Progress in novel cellular therapy options for chronic lymphocytic leukemia: the M D Anderson perspective.

Nina Shah, Katy Rezvani, Chitra Hosing, Partow Kebriaei, William Wierda, Laurence Cooper, Elizabeth Shpall

Abstract readReview
In one paragraph

Review in Clinical lymphoma, myeloma & leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nina ShahDepartment of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: nshah@mdanderson.org.
Katy RezvaniDepartment of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX.
Chitra HosingDepartment of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX.
Partow KebriaeiDepartment of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX.
William WierdaDepartment of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX.
Laurence CooperDepartment of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX.
Elizabeth ShpallDepartment of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
NCI NIH HHS L30 CA154037NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Over the past several years there has been considerable progress in the number and breadth of therapeutic options for patients with chronic lymphocytic leukemia. In particular, cumulative experience with stem cell transplant and immunotherapy has made these modalities more available to a broader range of patients. Advances in genetic engineering and ex vivo expansion techniques have sculpted cellular therapy products to optimize the combination of specificity and toxicity. This brief review discusses recent cutting-edge experience with chimeric antigen receptor T cells as well as developing cellular therapy products at the authors' institution.

Indexed as

Adoptive TransferCell- and Tissue-Based TherapyHumansImmunotherapyKiller Cells, NaturalLeukemia, Lymphocytic, Chronic, B-CellReceptors, Antigen, T-CellRecombinant Fusion ProteinsT-LymphocytesReceptors, Antigen, T-CellRecombinant Fusion ProteinsChimeric antigen receptorsImmunotherapyNK cellsStem cell transplantT cells

Identifiers

PMID25486950
PMCPMC4844462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.