Evidence map›Paper›PMID 25486905›Full record

ArticleWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Chronic wound repair and healing in older adults: current status and future research.

Lisa Gould, Peter Abadir, Harold Brem, Marissa Carter, Teresa Conner-Kerr, Jeff Davidson, Luisa DiPietro, Vincent Falanga, Caroline Fife, Sue Gardner and 19 more

3 registry-linked trialsAbstract read
In one paragraph

Article in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04750837 phase2completednot on this map

Autologous Platelet-Rich Plasma Versus Conventional Dressing Method in the Treatment of Chronic Diabetic Foot Ulcers

TypeinterventionalSponsorZagazig UniversityRan2020 to 2021Enrolled72ConditionsPlatelet Rich PlasmaArmsdebridement of the wound, platelet rich plasma, conventional dressing
NCT05588583 narecruitingnot on this map

A Prospective, Open, Multi-Center, Interventional, Non-Comparative Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up

TypeinterventionalSponsorMolnlycke Health Care ABRan2022 to 2024Enrolled68ConditionsWounds, Wound of Skin, Wound Leg, WoundArmsMepilex Up
NCT05608317 narecruitingnot on this map

A Prospective, Open, Multi-Center, Interventional, Non-Comparative Clinical Investigation to Follow the Progress of Exuding Venous Leg Ulcers Using a Non-Bordered Foam Dressing

TypeinterventionalSponsorMolnlycke Health Care ABRan2022 to 2024Enrolled20ConditionsWounds, Wound of Skin, Wound Leg, Venous Leg UlcerArmsALLEVYN Non-Adhesive
3 · Its place in the literature

Who cites it

108 citing papers in PubMed.

  1. Trial
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  4. Review
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  8. Review
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  13. Review
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  16. Review
  17. Article
  18. Risk factors for rehospitalization after trauma: a follow-up study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
  19. Observational
  20. Fibroblast-Mediated Macrophage Recruitment Supports Acute Wound Healing.The Journal of investigative dermatology · 2025
    Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Lisa GouldWound Recovery and Hyperbaric Medicine Center, Kent Hospital, Warwick, Rhode Island.
Peter Abadir
Harold Brem
Marissa Carter
Teresa Conner-Kerr
Jeff Davidson
Luisa DiPietro
Vincent Falanga
Caroline Fife
Sue Gardner
Elizabeth Grice
John Harmon
William R Hazzard
Kevin P High
Pamela Houghton
Nasreen Jacobson
Robert S Kirsner
Elizabeth J Kovacs
David Margolis
Frances McFarland Horne
May J Reed
Dennis H Sullivan
Stephen Thom
Marjana Tomic-Canic
Jeremy Walston
JoAnne Whitney
John Williams
Susan Zieman
Kenneth Schmader

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
Stem cell mobilization and diabetic skin ulcersR01DK094260 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MARGOLIS, DAVID, THOM, STEPHEN RAYMOND · 2012 to 2016
$2.7M
Clinical Research Center to Decrease Limb Amputation Rate in People with DiabetesK24DK090135 · NIDDK · NYU WINTHROP HOSPITAL · PI BREM, HAROLD · 2011 to 2015
$654k
A Transdisciplinary Approach to Engage Specialty Investigators in Aging ResearchU13AG040938 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HIGH, KEVIN P., KRITCHEVSKY, STEPHEN B. · 2011 to 2019
$423k
NIA NIH HHS 1U13 AG040938 01NIA NIH HHS P30 AG021334NIA NIH HHS P30 AG028716NIA NIH HHS U13 AG040938NIDDK NIH HHS K24 DK090135NIDDK NIH HHS R01 DK094260
6 · The paper itself

Abstract

The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi-morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection, and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this paper, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify key research questions to guide future study of age-associated changes in chronic wound healing.

Indexed as

AgingAdministration, TopicalAgedAged, 80 and overAge FactorsAnimalsAnti-Infective AgentsCanadaChronic DiseaseComorbidityDisease ProgressionElectric Stimulation TherapyFemaleHumansMaleMiceAnti-Infective Agents

Identifiers

PMID25486905
PMCPMC4414710

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.