ArticleJournal of structural biology2015
Semi-automated selection of cryo-EM particles in RELION-1.3.
Article in Journal of structural biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 234 papers.
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Who cites it
234 citing papers in PubMed.
- Article
- Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter.Nature communications · 2026Article
- Conformational changes of the baseplate regulating tail contraction of Staphylococcus phage 812.The EMBO journal · 2026Article
- Conformational hijacking of lipoprotein transporter LolDF enables precision antimicrobial activity against Acinetobacter baumannii.Nature communications · 2026Article
- CryoFSL: an annotation-efficient, few-shot learning framework for robust protein particle picking in cryo-electron microscopy micrographs.Briefings in bioinformatics · 2026Article
- Psychedelics elicit their effects by 5-HTNature · 2026Article
- CryoSIP: unleashing protein high-resolution Cryo-EM via semantic-instance collaborative picking.Briefings in bioinformatics · 2026Article
- Point cloud deformation modeling for particle selection following cryo-EM 2D classification.BMC bioinformatics · 2026Article
- Subspace Method of Moments forSIAM journal on imaging sciences · 2026Article
- CryoFSL: An Annotation-Efficient, Few-Shot Learning Framework for Robust Protein Particle Picking in Cryo-EM Micrographs.bioRxiv : the preprint server for biology · 2025Article
- Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant NaProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Self-supervised learning for generalizable particle picking in cryo-EM micrographs.Cell reports methods · 2025Article
- Advancing time-resolved structural biology: latest strategies in cryo-EM and X-ray crystallography.Nature methods · 2025Review
- Article
- RNA sample optimization for cryo-EM analysis.Nature protocols · 2025Review
- Structural basis for the substrate recognition and transport mechanism of the human yScience advances · 2025Article
- AI-based methods for biomolecular structure modeling for Cryo-EM.Current opinion in structural biology · 2025Review
- Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE.Signal transduction and targeted therapy · 2024Article
- EMhub: a web platform for data management and on-the-fly processing in scientific facilities.Acta crystallographica. Section D, Structural biology · 2024Article
- Article
174 more citing papers are in PubMed but not listed here.
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Abstract
The selection of particles suitable for high-resolution cryo-EM structure determination from noisy micrographs may represent a tedious and time-consuming step. Here, a semi-automated particle selection procedure is presented that has been implemented within the open-source software RELION. At the heart of the procedure lies a fully CTF-corrected template-based picking algorithm, which is supplemented by a fast sorting algorithm and reference-free 2D class averaging to remove false positives. With only limited user-interaction, the proposed procedure yields results that are comparable to manual particle selection. Together with an improved graphical user interface, these developments further contribute to turning RELION from a stand-alone refinement program into a convenient image processing pipeline for the entire single-particle approach.
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