Evidence map›Paper›PMID 25486603›Full record

ArticleClinical immunology (Orlando, Fla.)2015

METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages.

Irina Ushach, Amanda M Burkhardt, Cynthia Martinez, Peter A Hevezi, Peter Arne Gerber, Bettina Alexandra Buhren, Holger Schrumpf, Ricardo Valle-Rios, Monica I Vazquez, Bernhard Homey and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical immunology (Orlando, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 143 citations in OpenAlex.

  1. Article
  2. Metrnl in mitigating radiation enteritisActa pharmaceutica Sinica. B · 2026
    Article
  3. Review
  4. Metrnl in health and disease: tissue-specific actions and signaling networks.Apoptosis : an international journal on programmed cell death · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. The M2 Macrophages Importance Role in Psoriasis.Immunity, inflammation and disease · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Irina UshachDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA.
Amanda M BurkhardtDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA.
Cynthia MartinezDepartment of Dermatology, School of Medicine, University of Duesseldorf, Duesseldorf, Germany.
Peter A HeveziDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA.
Peter Arne GerberDepartment of Dermatology, School of Medicine, University of Duesseldorf, Duesseldorf, Germany.
Bettina Alexandra BuhrenDepartment of Dermatology, School of Medicine, University of Duesseldorf, Duesseldorf, Germany.
Holger SchrumpfDepartment of Dermatology, School of Medicine, University of Duesseldorf, Duesseldorf, Germany.
Ricardo Valle-RiosDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA; Present address: Laboratory of Immunology and Proteomics, Children's Hospital of Mexico, Mexico, D.F. 06720, Mexico.
Monica I VazquezDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA.
Bernhard HomeyDepartment of Dermatology, School of Medicine, University of Duesseldorf, Duesseldorf, Germany.
Albert ZlotnikDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA, USA; Institute for Immunology, University of California Irvine, Irvine, CA, USA. Electronic address: azlotnik@uci.edu.
University of California, Irvine · USHeinrich Heine University Düsseldorf · DE

Funding

Immunology Research Training ProgramT32AI060573 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2005 to 2020
$1.9M
Characterization of IL36, a novel cytokineR21AI096278 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI ZLOTNIK, ALBERT · 2011 to 2012
$406k
NIAID NIH HHS R21 AI096278NIAID NIH HHS R21AI096278-01NIAID NIH HHS T32 AI060573
6 · The paper itself

Abstract

Cytokines are involved in many functions of the immune system including initiating, amplifying and resolving immune responses. Through bioinformatics analyses of a comprehensive database of gene expression (BIGE: Body Index of Gene Expression) we observed that a small secreted protein encoded by a poorly characterized gene called meteorin-like (METRNL), is highly expressed in mucosal tissues, skin and activated macrophages. Further studies indicate that Metrnl is produced by Alternatively Activated Macrophages (AAM) and M-CSF cultured bone marrow macrophages (M2-like macrophages). In the skin, METRNL is expressed by resting fibroblasts and IFNγ-treated keratinocytes. A screen of human skin-associated diseases showed significant over-expression of METRNL in psoriasis, prurigo nodularis, actinic keratosis and atopic dermatitis. METRNL is also up-regulated in synovial membranes of human rheumatoid arthritis. Taken together, these results indicate that Metrnl represents a novel cytokine, which is likely involved in both innate and acquired immune responses.

Indexed as

AnimalsArthritis, RheumatoidBone Marrow CellsCells, CulturedCytokinesDermatitis, AtopicEndothelial CellsHumansKeratinocytesKeratosis, ActinicMacrophage ActivationMacrophagesMiceMice, Inbred BALB CMice, Inbred C57BLNerve Growth Factorscometin protein, mouseCytokinesNerve Growth FactorsCytokineM2 macrophagesMeteorin-likePsoriasisRheumatoid arthritisSkin

Identifiers

PMID25486603
PMCPMC4336607
OpenAlexW2121191508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.