ArticleeLife2014
Cis-interactions between Notch and its ligands block ligand-independent Notch activity.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Horizontal basal cells self-govern their neurogenic potential during injury-induced regeneration of the olfactory epithelium.Development (Cambridge, England) · 2023Article
- Notch signaling sculpts the stem cell niche.Frontiers in cell and developmental biology · 2022Review
- Human limbal epithelial stem cell regulation, bioengineering and function.Progress in retinal and eye research · 2021Review
- Distant activation of Notch signaling induces stem cell niche assembly.PLoS genetics · 2021Article
- Multifaceted regulation of Notch signaling by glycosylation.Glycobiology · 2021Review
- Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development.Scientific reports · 2020Article
- A Comparison of Methods for Isolation of Limbal Niche Cells: Maintenance of Limbal Epithelial Stem/Progenitor Cells.Investigative ophthalmology & visual science · 2020Article
- Different modes of Notch activation and strength regulation in the spermathecal secretory lineage.Development (Cambridge, England) · 2020Article
- Making sense out of missense mutations: Mechanistic dissection of Notch receptors through structure-function studies in Drosophila.Development, growth & differentiation · 2020Review
- Vascular Notch Signaling in Stress Hematopoiesis.Frontiers in cell and developmental biology · 2020Review
- Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms.Journal of clinical medicine · 2019Review
- Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture.Scientific reports · 2019Article
- Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro.Scientific reports · 2019Article
- NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Inhibition of Notch signaling by the p105 and p180 subunits ofJournal of cell science · 2019Article
- Mechanosensitivity of Jagged-Notch signaling can induce a switch-type behavior in vascular homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- The Notch pathway regulates the Second Mitotic Wave cell cycle independently of bHLH proteins.Developmental biology · 2017Article
- The Ecdysone and Notch Pathways Synergistically Regulate Cut at the Dorsal-Ventral Boundary in Drosophila Wing Discs.Journal of genetics and genomics = Yi chuan xue bao · 2016Article
- Automatic stage identification of Drosophila egg chamber based on DAPI images.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Notch pathway is integrated into numerous developmental processes and therefore is fine-tuned on many levels, including receptor production, endocytosis, and degradation. Notch is further characterized by a twofold relationship with its Delta-Serrate (DSL) ligands, as ligands from opposing cells (trans-ligands) activate Notch, whereas ligands expressed in the same cell (cis-ligands) inhibit signaling. We show that cells without both cis- and trans-ligands can mediate Notch-dependent developmental events during Drosophila oogenesis, indicating ligand-independent Notch activity occurs when the receptor is free of cis- and trans-ligands. Furthermore, cis-ligands can reduce Notch activity in endogenous and genetically induced situations of elevated trans-ligand-independent Notch signaling. We conclude that cis-expressed ligands exert their repressive effect on Notch signaling in cases of trans-ligand-independent activation, and propose a new function of cis-inhibition which buffers cells against accidental Notch activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.