ArticleCell cycle (Georgetown, Tex.)2014
Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Loss of CDKN1B induces an age-related clonal hematopoietic disorder via Notch2 activity dysregulation.Cancer communications (London, England) · 2023Article
- HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel.Cell death & disease · 2022Article
- p27kip1 expression and phosphorylation dictate Palbociclib sensitivity in KRAS-mutated colorectal cancer.Cell death & disease · 2021Article
- CDKN1B mutation and copy number variation are associated with tumor aggressiveness in luminal breast cancer.The Journal of pathology · 2021Article
- A non-canonical role for p27Kip1 in restricting proliferation of corneal endothelial cells during development.PloS one · 2020Article
- Stathmin 1 Induces Murine Hepatocyte Proliferation and Increased Liver Mass.Hepatology communications · 2020Article
- Article
- Proliferation of hippocampal progenitors relies on p27-dependent regulation of Cdk6 kinase activity.Cellular and molecular life sciences : CMLS · 2018Article
- p27 inhibits CDK6/CCND1 complex formation resulting in cell cycle arrest and inhibition of cell proliferation.Cell cycle (Georgetown, Tex.) · 2018Article
- Landscape of CDKN1B Mutations in Luminal Breast Cancer and Other Hormone-Driven Human Tumors.Frontiers in endocrinology · 2018Review
- Akt/p27International journal of endocrinology · 2018Article
- CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation.EMBO molecular medicine · 2017Article
- Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells.Scientific reports · 2017Article
- p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms.Oncotarget · 2016Article
- Upregulation of MiR-196a promotes cell proliferation by downregulating p27Biological research · 2016Article
- Stathmin-dependent molecular targeting therapy for malignant tumor: the latest 5 years' discoveries and developments.Journal of translational medicine · 2016Review
- The non-canonical functions of p27(Kip1) in normal and tumor biology.Cell cycle (Georgetown, Tex.) · 2016Review
- Meet me in the cytoplasm: A role for p27(Kip1) in the control of H-Ras.Small GTPases · 2016Review
- Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.Journal of molecular histology · 2016Article
- Stathmin1 increases radioresistance by enhancing autophagy in non-small-cell lung cancer cells.OncoTargets and therapy · 2016Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The CDK inhibitor p27(kip1) is a critical regulator of cell cycle progression, but the mechanisms by which p27(kip1) controls cell proliferation in vivo are still not fully elucidated. We recently demonstrated that the microtubule destabilizing protein stathmin is a relevant p27(kip1) binding partner. To get more insights into the in vivo significance of this interaction, we generated p27(kip1) and stathmin double knock-out (DKO) mice. Interestingly, thorough characterization of DKO mice demonstrated that most of the phenotypes of p27(kip1) null mice linked to the hyper-proliferative behavior, such as the increased body and organ weight, the outgrowth of the retina basal layer and the development of pituitary adenomas, were reverted by co-ablation of stathmin. In vivo analyses showed a reduced proliferation rate in DKO compared to p27(kip1) null mice, linked, at molecular level, to decreased kinase activity of CDK4/6, rather than of CDK1 and CDK2. Gene expression profiling of mouse thymuses confirmed the phenotypes observed in vivo, showing that DKO clustered with WT more than with p27 knock-out tissue. Taken together, our results demonstrate that stathmin cooperates with p27(kip1) to control the early phase of G1 to S phase transition and that this function may be of particular relevance in the context of tumor progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.