Evidence map›Paper›PMID 25486562›Full record

ArticleCell cycle (Georgetown, Tex.)2014

ISWI chromatin remodeling complexes in the DNA damage response.

Özge Z Aydin, Wim Vermeulen, Hannes Lans

Open access · hybridAbstract read
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 119 citations in OpenAlex.

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  9. Human mutation · 2025
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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Özge Z Aydina Department of Genetics ; Cancer Genomics Netherlands; Erasmus MC ; Rotterdam , The Netherlands.
Wim Vermeulen
Hannes Lans
Erasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regulation of chromatin structure is an essential component of the DNA damage response (DDR), which effectively preserves the integrity of DNA by a network of multiple DNA repair and associated signaling pathways. Within the DDR, chromatin is modified and remodeled to facilitate efficient DNA access, to control the activity of repair proteins and to mediate signaling. The mammalian ISWI family has recently emerged as one of the major ATP-dependent chromatin remodeling complex families that function in the DDR, as it is implicated in at least 3 major DNA repair pathways: homologous recombination, non-homologous end-joining and nucleotide excision repair. In this review, we discuss the various manners through which different ISWI complexes regulate DNA repair and how they are targeted to chromatin containing damaged DNA.

Indexed as

DNA RepairAdenosine TriphosphatasesAnimalsChromatinChromatin Assembly and DisassemblyDNA Breaks, Double-StrandedDrosophilaHistonesMicroRNAsSignal TransductionAdenosine TriphosphatasesChromatinHistonesMicroRNAsACF1ACF1, ATP-utilizing Chromatin assembly and remodeling Factor 1ATP-dependent chromatin remodelingBER, Base Excision RepairDDR, DNA Damage ResponseDNA damage responseDSB, Double Strand BreakGG-NER, Global Genome Nucleotide Excision RepairHomologous RecombinationHR, Homologous RecombinationISWIISWI, Imitation SWItchMRN, MRE11/Rad50/NBS1NER, Nucleotide Excision RepairNHEJ, Non-Homologous End JoiningNon-Homologous End-JoiningNucleotide Excision RepairPAR, Poly(ADP-Ribose)RNApolII, RNA Polymerase IIRSF1, Remodeling and Spacing Factor 1SMARCA5/SNF2HSMARCA, SWI-SNF-related Matrix-associated Actin-dependent Regulator of Chromatin ATC-NER, Transcription-Coupled Nucleotide Excision RepairWSTFWSTF, Williams Syndrome Transcription Factor

Identifiers

PMID25486562
PMCPMC4615051
OpenAlexW2156970346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.