Evidence map›Paper›PMID 25486483›Full record

ArticleCell cycle (Georgetown, Tex.)2014

Epithelial cell-derived periostin functions as a tumor suppressor in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14ARF/Mdm2 signaling pathway.

Hongjun Lv, Rui Liu, Jiao Fu, Qi Yang, Jing Shi, Pu Chen, Meiju Ji, Bingyin Shi, Peng Hou

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. The Prognostic Value of Periostin Expression in Non-Small Cell Lung Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Pooled it
  2. Review
  3. Article
  4. POSTN: a Potential Therapeutic Target in the Treatment of Gastric Cancer?Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Article
  5. Periostin: biology and function in cancer.Cancer cell international · 2022
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Role of extra cellular proteins in gastric cancer progression and metastasis: an update.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2020
    Review
  12. Integrated Analysis Revealed Prognostic Factors for Prostate Cancer Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Hongjun Lva Department of Endocrinology ; The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine ; Xi'an , The People's Republic of China.
Rui Liu
Jiao Fu
Qi Yang
Jing Shi
Pu Chen
Meiju Ji
Bingyin Shi
Peng Hou
First Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periostin is usually considered as an oncogene in diverse human cancers, including breast, prostate, colon, esophagus, and pancreas cancers, whereas it acts as a tumor suppressor in bladder cancer. In gastric cancer, it has been demonstrated that periglandular periostin expression is decreased whereas stromal periostin expression is significantly increased as compared with normal gastric tissues. Moreover, periostin produced by stromal myofibroblasts markedly promotes gastric cancer cell growth. These observations suggest that periostin derived from different types of cells may play distinct biological roles in gastric tumorigenesis. The aim of this study was to explore the biological functions and related molecular mechanisms of epithelial cell-derived periostin in gastric cancer. Our data showed that periglandular periostin was significantly down-regulated in gastric cancer tissues as compared with matched normal gastric mucosa. In addition, its expression in metastatic lymph nodes was significantly lower than that in their primary cancer tissues. Our data also demonstrated that periglandular periostin expression was negatively associated with tumor stage. More importantly, restoration of periostin expression in gastric cancer cells dramatically suppressed cell growth and invasiveness. Elucidation of the mechanisms involved revealed that periostin restoration enhanced Rb phosphorylation and sequentially activated the transcription of E2F1 target gene p14(ARF), leading to Mdm2 inactivation and the stabilization of p53 and E-cadherin proteins. Strikingly, these effects of periostin were abolished upon Rb deletion. Collectively, we have for the first time demonstrated that epithelial cell-derived periostin exerts tumor-suppressor activities in gastric cancer through stabilizing p53 and E-cadherin proteins via the Rb/E2F1/p14(ARF)/Mdm2 signaling pathway.

Indexed as

Signal TransductionAntigens, CDApoptosisCadherinsCell Adhesion MoleculesCell Cycle CheckpointsCell Line, TumorCell MovementCell ProliferationDown-RegulationE2F1 Transcription FactorEpithelial CellsHumansNeoplasm InvasivenessProtein StabilityProto-Oncogene Proteins c-mdm2Antigens, CDCadherinsCDH1 protein, humanCell Adhesion MoleculesE2F1 protein, humanE2F1 Transcription FactorMDM2 protein, humanPOSTN protein, humanProto-Oncogene Proteins c-mdm2Retinoblastoma ProteinTumor Suppressor Protein p14ARFTumor Suppressor Protein p533-[45-dimethylthiazol-2-yl]-25-diphenyl tetrazolium bromide; NSCLCAbbreviations: Akt/PKBdimethyl sulfoxide; E2F1Dulbecco's modified Eagles medium; DMSOE2F transcription factor 1; ECME-cadherinenzyme linked immunosorbent assay; EMTepidermal growth factor receptor; ELISAepithelial-to-mesenchymal transition; ESCCesophageal squamous cell carcinoma; FAKEthylenediaminetetraacetic acid; EGFRextracellular matrix; EDTAfluoresceine isothiocyanate; HRPfocal adhesion kinase; FITCGastric cancerhorseradish peroxidase; HCimmunohistochemistry; Mdm2Mdm2metalloproteinases; MTTmouse double minute 2; MMPsnon-small-cell lung cancer; PBSp53periostinphosphate buffered saline; PI3Kphosphatidylinositol 3-kinase; PVDFpolyvinylidene fluoride; RbRb/E2F1 pathwayretinoblastoma; RPMI 1640Reverse-transcription polymerase chain reaction; SDS-PAGERoswell Park Memorial Institute 1640; RT-PCRSentrin-specific protease 8; shRNAserine/threonine kinase/protein kinase B; DMEMshort hairpin RNA.sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SENP8

Identifiers

PMID25486483
PMCPMC4614259
OpenAlexW2012058487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.