ArticlePloS one2014
Hyperthyroid and hypothyroid status was strongly associated with gout and weakly associated with hyperuricaemia.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Observational
- Impact of rs2046045 SNP in PDE8B on TSH Levels: Insights into Genetic Susceptibility to Hypothyroidism.Biochemical genetics · 2025Article
- Effects of thyroid-stimulating hormone and sensitivity to thyroid hormones on the risk of hyperuricemia in euthyroid adults.Archives of endocrinology and metabolism · 2025Observational
- The Relationship Between Thyroid Function Status and Serum Uric Acid Levels Based on a Restricted Cubic Spline Model: A Cross-Sectional Study.Risk management and healthcare policy · 2025Article
- Impaired sensitivity to thyroid hormones is associated with ASCVD risk factors in Beijing in euthyroid population: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Uric Acid Status in Subclinical Hypothyroidism.EJIFCC · 2024Review
- Increased risk of incident gout in patients with hyperthyroidism: a nationwide retrospective cohort study.Rheumatology international · 2024Article
- Hypothyroidism, comorbidity and health-related quality of life: a population-based study.Endocrine connections · 2023Article
- The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort.Journal of personalized medicine · 2022Article
- Gender and Age-Specific Differences in the Association of Thyroid Function and Hyperuricemia in Chinese: A Cross-Sectional Study.International journal of endocrinology · 2022Article
- The Association with Subclinical Thyroid Dysfunction and Uric Acid.International journal of endocrinology · 2021Review
- Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies.International journal of endocrinology · 2021Review
- Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction.The Journal of international medical research · 2020Article
- Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.Irish journal of medical science · 2019Article
- Functional Urate-Associated Genetic Variants Influence Expression of lincRNAsFrontiers in genetics · 2018Article
- The association between thyroid disorders and incident gout: population-based case-control study.Clinical epidemiology · 2017Article
- Impact of gout on the risk of atrial fibrillation.Rheumatology (Oxford, England) · 2016Article
- Physical Function, Hyperuricemia, and Gout in Older Adults.Arthritis care & research · 2015Article
- Increase in thyroid stimulating hormone levels in patients with gout treated with inhibitors of xanthine oxidoreductase.Rheumatology international · 2015Observational
- Global epidemiology of gout: prevalence, incidence and risk factors.Nature reviews. Rheumatology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to estimate the risk of hyperuricaemia and gout in people with hypothyroid or hyperthyroid status.
methodsThis study analyzed data from individuals who participated in health screening programs at Chang Gung Memorial Hospital in northern Taiwan (2000-2010). Participants were categorized as having euthyroid, hypothyroid, or hyperthyroid status according to their thyroid-stimulating hormone (TSH) levels. Multinomial logistic regression models were used to calculate the odds ratios (95% CI) for hyperuricaemia and gout in participants with thyroid dysfunction compared to euthyroid participants.
resultsA total of 87,813 (euthyroid, 83,502; hypothyroid, 1,460; hyperthyroid, 2,851) participants were included. The prevalence of hyperuricaemia was higher in hyperthyroid subjects (19.4%) than in euthyroid subjects (17.8%) but not in hypothyroid subjects (19.3%). The prevalence of gout was significantly higher in both hypothyroid (6.0%) and hyperthyroid (5.3%) subjects than in euthyroid subjects (4.3%). In men, hypothyroid or hyperthyroid status was not associated with hyperuricaemia. However, hypothyroid or hyperthyroid status was associated with ORs (95% CI) of 1.47 (1.10-1.97) and 1.37 (1.10-1.69), respectively, for gout. In women, hypothyroid status was not associated with hyperuricaemia or gout. However, hyperthyroid status was associated with ORs (95% CI) of 1.42 (1.24-1.62) for hyperuricaemia and 2.13 (1.58-2.87) for gout.
conclusionsBoth hyperthyroid and hypothyroid status were significantly associated with gout and weakly associated with hyperuricaemia. A thyroid function test for gout patients may by warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.