ArticleJournal of studies on alcohol and drugs2015
Family history density of alcoholism relates to left nucleus accumbens volume in adolescent girls.
Article in Journal of studies on alcohol and drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 48 citations in OpenAlex.
- Intertemporal Decision-Making, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults With a Family History of Alcohol Use Disorder.Alcohol, clinical & experimental research · 2026Article
- Delay Discounting, Nucleus Accumbens Activation, and Alcohol Use Trajectories in Young Adults with a Family History of Alcohol Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.medRxiv : the preprint server for health sciences · 2025Article
- The effects of alcohol use severity and polygenic risk on gray matter volumes in young adults.Frontiers in psychiatry · 2025Article
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- Naltrexone engages a brain reward network in the presence of reward-predictive distractor stimuli in males.Addiction neuroscience · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Differences in parent and youth perceived neighborhood threat on nucleus accumbens-frontoparietal network resting state connectivity and alcohol sipping in children enrolled in the ABCD study.Frontiers in psychiatry · 2023Article
- Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.Human brain mapping · 2022Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Pathways to post-traumatic stress disorder and alcohol dependence: Trauma, executive functioning, and family history of alcoholism in adolescents and young adults.Brain and behavior · 2020Article
- Association of Gray Matter and Personality Development With Increased Drunkenness Frequency During Adolescence.JAMA psychiatry · 2020Article
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- Association Between Age and Familial Risk for Alcoholism on Functional Connectivity in Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Naltrexone Acutely Enhances Connectivity Between the Ventromedial Prefrontal Cortex and a Left Frontoparietal Network.Alcoholism, clinical and experimental research · 2019Article
- Does Family History of Alcohol Use Disorder Relate to Differences in Regional Brain Volumes? A Descriptive Review with New Data.Alcoholism, clinical and experimental research · 2018Article
- Sex Differences in the Developmental Neuroscience of Adolescent Substance Use Risk.Current opinion in behavioral sciences · 2018Article
- Sexual risk-taking and subcortical brain volume in adolescence.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Article
- Sex Specific Alterations in α4*Nicotinic Receptor Expression in the Nucleus Accumbens.Brain sciences · 2018Article
- Effects of adolescent alcohol consumption on the brain and behaviour.Nature reviews. Neuroscience · 2018Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveA family history of alcoholism is a significant risk factor for the development of alcohol use disorders (AUDs). Because common structural abnormalities are present in reward and affective brain regions in alcoholics and those with familial alcoholism, the current study examined the relationship between familial loading of AUDs and volumes of the amygdala and nucleus accumbens (NAcc) in largely alcohol-naive adolescents, ages 12-16 years (N = 140).
methodThe amygdala and NAcc were delineated on each participant's T1-weighted anatomical scan, using FMRIB Software Library's FMRIB Integrated Registration & Segmentation Tool, and visually inspected for accuracy and volume outliers. In the 140 participants with accurate segmentation (75 male/65 female), subcortical volumes were represented as a ratio to intracranial volume (ICV). A family history density (FHD) score was calculated for each adolescent based on the presence of AUDs in first- and second-degree relatives (range: 0.03-1.50; higher scores represent a greater prevalence of familial AUDs). Multiple regressions, with age and sex controlled for, examined the association between FHD and left and right amygdala and NAcc volume/ICV.
resultsThere was a significant positive relationship between FHD and left NAcc volume/ICV (ΔR² = .04, p = .02). Post hoc regressions indicated that this effect was only significant in females (ΔR² = .11, p = .006).
conclusionsThis finding suggests that the degree of familial alcoholism, genetic or otherwise, is associated with alterations in reward-related brain structure. Further work will be necessary to examine whether FHD is related to future alcohol-related problems and reward-related behaviors.
Indexed as
Identifiers
25486393PMC4263780W2149956732What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.