ArticleCell cycle (Georgetown, Tex.)2014
Autophagy functions on EMT in gastrulation of avian embryo.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Review
- Insights on E1-like enzyme ATG7: functional regulation and relationships with aging-related diseases.Communications biology · 2024Review
- Autophagy regulation combined with stem cell therapy for treatment of spinal cord injury.Neural regeneration research · 2023Review
- A novel region within a conserved domain in ATG7 emerged in vertebrates.Autophagy reports · 2022Article
- Upregulation of ASPP2 expression alleviates the development of proliferative vitreoretinopathy in a rat model.International journal of ophthalmology · 2021Article
- Hyperoxia reduces STX17 expression and inhibits the autophagic flux in alveolar type II epithelial cells in newborn rats.International journal of molecular medicine · 2020Article
- Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways.Immunology · 2020Review
- KRT8 phosphorylation regulates the epithelial-mesenchymal transition in retinal pigment epithelial cells through autophagy modulation.Journal of cellular and molecular medicine · 2020Article
- Association Study of Genetic Variants in Autophagy Pathway and Risk of Non-syndromic Cleft Lip With or Without Cleft Palate.Frontiers in cell and developmental biology · 2020Article
- Autophagy-related 7 modulates tumor progression in triple-negative breast cancer.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells.Autophagy · 2019Article
- Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis.Journal of experimental & clinical cancer research : CR · 2018Article
- The role of autophagy in morphogenesis and stem cell maintenance.Histochemistry and cell biology · 2018Review
- Atg7-Mediated Autophagy Is Involved in the Neural Crest Cell Generation in Chick Embryo.Molecular neurobiology · 2018Article
- The impact of autophagy on the development of senescence in primary tubular epithelial cells.Cell cycle (Georgetown, Tex.) · 2016Article
- Proper autophagy is indispensable for angiogenesis during chick embryo development.Cell cycle (Georgetown, Tex.) · 2016Article
- High glucose environment inhibits cranial neural crest survival by activating excessive autophagy in the chick embryo.Scientific reports · 2015Article
- Autophagy is involved in ethanol-induced cardia bifida during chick cardiogenesis.Cell cycle (Georgetown, Tex.) · 2015Article
- Snail promotes epithelial-mesenchymal transition and invasiveness in human ovarian cancer cells.International journal of clinical and experimental medicine · 2015Article
- Autophagy is involved in high glucose-induced heart tube malformation.Cell cycle (Georgetown, Tex.) · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is important for cell renewing for its contribution to the degradation of bulk cytoplasm, long-lived proteins, and entire organelles and its role in embryonic development is largely unknown. In our study, we investigated the function of autophagy in gastrulation of the chick embryo using both in vivo and in vitro approaches, especially in the EMT process, and we found that autophagy gene Atg7 was expressed on the apical side of the ectoderm and endoderm. Over-expression of Atg7 could enhance the expression of Atg8 and the E-cadherin, the latter of which is a crucial marker of the EMT process. We also found that the disturbance of autophagy could retard the development of chick embryos in HH4 with shorter primitive steak than that in the control group, which is a newly formed structure during EMT process. So we assumed that autophagy could affect EMT process by adhesion molecule expression. Moreover, more molecules, such as slug, chordin, shh et., which were all involved in EMT process, were detected to address the mechanism of this phenomena. We established that the inhibition of autophagy could cause developmental delay by affecting EMT process in gastrulation of chick embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.