ArticleCell cycle (Georgetown, Tex.)2014
p53 shapes genome-wide and cell type-specific changes in microRNA expression during the human DNA damage response.
Article in Cell cycle (Georgetown, Tex.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- The emerging role of miRNAs in biological aging and age-related diseases.Non-coding RNA research · 2025Review
- An AI-assisted morphoproteomic approach is a supportive tool in esophagitis-related precision medicine.EMBO molecular medicine · 2025Article
- Article
- Downregulation of SATB1 by miRNAs reduces megakaryocyte/erythroid progenitor expansion in preclinical models of Diamond-Blackfan anemia.Experimental hematology · 2022Article
- MALAT-1/p53/miR-155/miR-146a ceRNA circuit tuned by methoxylated quercitin glycoside alters immunogenic and oncogenic profiles of breast cancer.Molecular and cellular biochemistry · 2022Article
- Aging and Protein Kinases.Advances in experimental medicine and biology · 2021Article
- Erb‑B2 Receptor Tyrosine Kinase 2 is negatively regulated by the p53‑responsive microRNA‑3184‑5p in cervical cancer cells.Oncology reports · 2021Observational
- Revealing a human p53 universe.Nucleic acids research · 2018Article
- Dynamics of p53: A Master Decider of Cell Fate.Genes · 2017Review
- Ex vivo miRNome analysis in Ptch1+/- cerebellum granule cells reveals a subset of miRNAs involved in radiation-induced medulloblastoma.Oncotarget · 2016Article
- Prognostic value of DNA repair based stratification of hepatocellular carcinoma.Scientific reports · 2016Article
- Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen.Radiation research · 2016Article
- The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration.Cell death & disease · 2016Article
- microRNAs are differentially regulated between MDM2-positive and negative malignant pleural mesothelioma.Oncotarget · 2016Article
- Article
- Micro(mi) RNA-34a targets protein phosphatase (PP)1γ to regulate DNA damage tolerance.Cell cycle (Georgetown, Tex.) · 2015Article
- The big player governs small world too.Cell cycle (Georgetown, Tex.) · 2014Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 5 countries.
Funding
Abstract
The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been implicated in the DDR, there is as yet no comprehensive description of genome-wide changes in the expression of miRNAs triggered by DNA breakage in human cells. We have used next-generation sequencing (NGS), combined with rigorous integrative computational analyses, to describe genome-wide changes in the expression of miRNAs during the human DDR. The changes affect 150 of 1523 miRNAs known in miRBase v18 from 4-24 h after the induction of DNA breakage, in cell-type dependent patterns. The regulatory regions of the most-highly regulated miRNA species are enriched in conserved binding sites for p53. Indeed, genome-wide changes in miRNA expression during the DDR are markedly altered in TP53-/- cells compared to otherwise isogenic controls. The expression levels of certain damage-induced, p53-regulated miRNAs in cancer samples correlate with patient survival. Our work reveals genome-wide and cell type-specific alterations in miRNA expression during the human DDR, which are regulated by the tumor suppressor protein p53. These findings provide a genomic resource to identify new molecules and mechanisms involved in the DDR, and to examine their role in tumor suppression and the clinical outcome of cancer patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.