ArticleNature nanotechnology2015
Continuous observation of the stochastic motion of an individual small-molecule walker.
Article in Nature nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Selective Identification of Allosteric Inhibitors and Co-Drug Combinations Targeting Kinases by Using a Nanopore Tweezer Approach.ACS nano · 2025Article
- Tracing the evolution of sequencing into the era of genomic medicine.Nature reviews. Genetics · 2025Review
- High-Resolution Patterned Delivery of Chemical Signals From 3D-Printed Picoliter Droplet Networks.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Mobile Molecules: Reactivity Profiling Guides Faster Movement on a Cysteine Track.Angewandte Chemie (International ed. in English) · 2023Article
- Mobile Molecules: Reactivity Profiling Guides Faster Movement on a Cysteine Track.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Article
- DNA Walkers for Biosensing Development.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Article
- Functionalised nanopores: chemical and biological modifications.Chemical science · 2022Review
- Thiol-Mediated Uptake.JACS Au · 2021Review
- Design, assembly, and characterization of membrane-spanning DNA nanopores.Nature protocols · 2021Article
- Single-Molecule Observation of Intermediates in Bioorthogonal 2-Cyanobenzothiazole Chemistry.Angewandte Chemie (International ed. in English) · 2020Article
- Catalytic transport of molecular cargo using diffusive binding along a polymer track.Nature chemistry · 2019Article
- Distinct functional elements for outer-surface anti-interference and inner-wall ion gating of nanochannels.Nature communications · 2018Article
- Role of outer surface probes for regulating ion gating of nanochannels.Nature communications · 2018Article
- DNA sequencing at 40: past, present and future.Nature · 2017Review
- Enzyme-Mediated Directional Transport of a Small-Molecule Walker With Chemically Identical Feet.Journal of the American Chemical Society · 2017Article
- Building membrane nanopores.Nature nanotechnology · 2017Review
- Nanopore Sensing.Analytical chemistry · 2017Review
- Article
- Semisynthetic protein nanoreactor for single-molecule chemistry.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Motion--whether it the ability to change shape, rotate or translate--is an important potential asset for functional nanostructures. For translational motion, a variety of DNA-based and small-molecule walkers have been created, but observing the translational motion of individual molecules in real time remains a significant challenge. Here, we show that the movement of a small-molecule walker along a five-foothold track can be monitored continuously within a protein nanoreactor. The walker is an organoarsenic(III) molecule with exchangeable thiol ligands, and the track a line of cysteine residues 6 Å apart within an α-haemolysin protein pore that acts as the nanoreactor. Changes in the flow of ionic current through the pore reflect the individual steps of a single walker, which require the making and breaking of As-S bonds, and occur in aqueous solution at neutral pH and room temperature. The walker moves considerably faster (∼0.7 s per step) than previous walkers based on covalent chemistry and is weakly processive (6 ± 1 steps per outing). It shows weak net directional movement, which can be described by a thermodynamic sink arising from the different environments of the cysteines that constitute the track.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.