ArticleNature methods2015
DNA nanoswitches: a quantitative platform for gel-based biomolecular interaction analysis.
Article in Nature methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Nonenzymatic Detection of SARS-CoV‑2 RNA Using DNA Nanoswitches.ACS nano medicine · 2026Article
- Aptamer-based DNA nanoswitches for multiplexed protein detection.Chemical communications (Cambridge, England) · 2026Article
- A 3D Printed Mini-Gel Electrophoresis System for Rapid and Inexpensive DNA Nanoswitch Biosensing.ACS measurement science au · 2026Article
- Ligation-assisted target recycling for DNA nanoswitch biosensors.bioRxiv : the preprint server for biology · 2026Article
- Aptamer-based DNA nanoswitches for multiplexed protein detection.bioRxiv : the preprint server for biology · 2026Article
- Light-Guided Molecular Patterning for High-Throughput Single-Molecule Mechanical Characterization.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- [Binary encryption comprehensive experiment based on agarose gel electrophoresis].Se pu = Chinese journal of chromatography · 2026Article
- A 3D printed mini-gel electrophoresis system for rapid and inexpensive DNA nanoswitch biosensing.bioRxiv : the preprint server for biology · 2026Article
- Catalytic Hairpin Assembly-Based Self-Ratiometric Gel Electrophoresis Detection Platform for Reliable Nucleic Acid Analysis.Biosensors · 2024Article
- Resolving altered base-pairing of RNA modifications with DNA nanoswitches.Nucleic acids research · 2023Article
- Multiplexed Nanopore-Based Nucleic Acid Sensing and Bacterial Identification Using DNA Dumbbell Nanoswitches.Journal of the American Chemical Society · 2023Article
- Encoding, Decoding, and Rendering Information in DNA Nanoswitch Libraries.ACS synthetic biology · 2023Article
- Resolving Molecular Heterogeneity with Single-Molecule Centrifugation.Journal of the American Chemical Society · 2023Article
- High-throughput single-molecule quantification of individual base stacking energies in nucleic acids.Nature communications · 2023Article
- Single species RNA purification using DNA nanoswitches.Trends in biochemical sciences · 2022Article
- Sequence-selective purification of biological RNAs using DNA nanoswitches.Cell reports methods · 2021Article
- Electrophoretic mobility shift as a molecular beacon-based readout for miRNA detection.Biosensors & bioelectronics · 2021Article
- Optoregulated force application to cellular receptors using molecular motors.Nature communications · 2021Article
- Single-molecule force spectroscopy reveals the dynamic strength of the hair-cell tip-link connection.Nature communications · 2021Article
- Reprogrammable Gel Electrophoresis Detection Assay Using CRISPR-Cas12a and Hybridization Chain Reaction.Analytical chemistry · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We introduce a nanoscale experimental platform that enables kinetic and equilibrium measurements of a wide range of molecular interactions using a gel electrophoresis readout. Programmable, self-assembled DNA nanoswitches serve both as templates for positioning molecules and as sensitive, quantitative reporters of molecular association and dissociation. We demonstrated this low-cost, versatile, 'lab-on-a-molecule' system by characterizing ten different interactions, including a complex four-body interaction with five discernible states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.