ArticlePloS one2014
Adverse obstetric and perinatal outcomes following treatment of adolescent and young adult cancer: a population-based cohort study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 5 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Pregnancy rate, maternal and neonatal outcomes among breast cancer survivors: A systematic review.Nursing open · 2023Pooled it
- Maternal and perinatal outcomes following a diagnosis of Hodgkin lymphoma during or prior to pregnancy: A systematic review.BJOG : an international journal of obstetrics and gynaecology · 2023Pooled it
- Multidisciplinary consensus on the criteria for fertility preservation in cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Guideline
- Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.Journal of cancer survivorship : research and practice · 2019Pooled it
- Pregnancy and child health outcomes in pediatric and young adult leukemia and lymphoma survivors: a systematic review.Leukemia & lymphoma · 2018Pooled it
- Pregnancy outcomes in women conceiving after hematopoietic stem cell transplantation versus conventional chemotherapy for childhood or adolescent acute leukemia.Bone marrow transplantation · 2026Article
- Impact of cancer during reproductive age on the probability of livebirth after cancer: a register-based cohort study among Danish women aged 18-39 with and without cancer.Journal of cancer survivorship : research and practice · 2026Article
- Racial and Ethnic Disparities in Adverse Pregnancy Outcomes Among Women with Early Onset Cancer in the United States.Cancers · 2026Article
- Joint effects of IVF and cancer history on birth outcomes.Journal of assisted reproduction and genetics · 2026Article
- Obstetric Complications and Pregnancy Outcomes in Cancer Survivors: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- The Impact of Radiotherapy on the Uterus and Its Implications for Pregnancy.Seminars in reproductive medicine · 2025Review
- Beating the Odds: A Successful Pregnancy in a Patient With ALK-Rearranged Lung Cancer on Alectinib.Case reports in medicine · 2025Article
- Adverse Obstetric Outcomes after Breast Cancer Diagnosis: An Observational Database Study in Germany.Cancers · 2024Article
- Sexual and reproductive complications and concerns of survivors of childhood, adolescent and adult cancer.Journal of cancer survivorship : research and practice · 2024Article
- Real Implication of Fertility-Sparing Surgery for Ovarian Cancer: Reproductive Outcomes.Diagnostics (Basel, Switzerland) · 2024Article
- Perinatal and childhood outcomes of children born to female cancer survivors in South Korea.Scientific reports · 2024Article
- Risk of adverse birth outcomes after adolescent and young adult cancer.JNCI cancer spectrum · 2024Article
- Birth Defects in Offspring of Adolescent and Young Adults with a History of Cancer: A Population-Based Study of 27,000 Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Cancer survivorship and risk of pregnancy complications, adverse obstetric outcomes, and maternal morbidities in female adolescents and young adults: a nationwide population-based study from Taiwan.British journal of cancer · 2023Article
- Maternal comorbidity and adverse perinatal outcomes in survivors of adolescent and young adult cancer: A cohort study.BJOG : an international journal of obstetrics and gynaecology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
objectiveTo investigate obstetric and perinatal outcomes among female survivors of adolescent and young adult (AYA) cancers and their offspring.
methodsUsing multivariate analysis of statewide linked data, outcomes of all first completed pregnancies (n = 1894) in female survivors of AYA cancer diagnosed in Western Australia during the period 1982-2007 were compared with those among females with no cancer history. Comparison pregnancies were matched by maternal age-group, parity and year of delivery.
resultsCompared with the non-cancer group, female survivors of AYA cancer had an increased risk of threatened abortion (adjusted relative risk 2.09, 95% confidence interval 1.51-2.74), gestational diabetes (2.65, 2.08-3.57), pre-eclampsia (1.32, 1.04-1.87), post-partum hemorrhage (2.83, 1.92-4.67), cesarean delivery (2.62, 2.22-3.04), and maternal postpartum hospitalization>5 days (3.01, 1.72-5.58), but no excess risk of threatened preterm delivery, antepartum hemorrhage, premature rupture of membranes, failure of labor to progress or retained placenta. Their offspring had an increased risk of premature birth (<37 weeks: 1.68, 1.21-2.08), low birth weight (<2500 g: 1.51, 1.23-2.12), fetal growth restriction (3.27, 2.45-4.56), and neonatal distress indicated by low Apgar score (<7) at 1 minute (2.83, 2.28-3.56), need for resuscitation (1.66, 1.27-2.19) or special care nursery admission (1.44, 1.13-1.78). Congenital abnormalities and perinatal deaths (intrauterine or ≤7 days of birth) were not increased among offspring of survivors.
conclusionFemale survivors of AYA cancer have moderate excess risks of adverse obstetric and perinatal outcomes arising from subsequent pregnancies that may require additional surveillance or intervention.
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