ArticleBehavioural pharmacology2015
Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats.
Article in Behavioural pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Eating a ketogenic diet enhances sensitivity of rats to the effects of methamphetamine, but not dopamine DPharmacology, biochemistry, and behavior · 2025Article
- Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses.Cell host & microbe · 2022Article
- Binge eating and psychostimulant addiction.World journal of psychiatry · 2021Review
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Evidence for Modulation of Substance Use Disorders by the Gut Microbiome: Hidden in Plain Sight.Pharmacological reviews · 2021Review
- Why did I eat that? Contributions of individual differences in incentive motivation and nucleus accumbens plasticity to obesity.Physiology & behavior · 2020Review
- Dietary supplementation with fish oil reverses high fat diet-induced enhanced sensitivity to the behavioral effects of quinpirole.Behavioural pharmacology · 2019Article
- Locomotor sensitization to cocaine in adolescent and adult female Wistar rats.Behavioural brain research · 2018Article
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole.Behavioural pharmacology · 2017Article
- Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet.Psychopharmacology · 2017Article
- High fat diet augments amphetamine sensitization in mice: Role of feeding pattern, obesity, and dopamine terminal changes.Neuropharmacology · 2016Article
- Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats.Drug and alcohol dependence · 2016Article
- Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning.European journal of pharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Eating high fat chow accelerates the development of sensitization to cocaine-induced locomotion in female rats. It is not known whether consumption of sucrose or saccharin also increases sensitivity to the behavioral effects of cocaine or whether continuous (or intermittent) access to these feeding conditions is necessary to change sensitivity. Adolescent female Sprague-Dawley rats were assigned to one of seven feeding conditions from postnatal day 25 through to postnatal day 60. The rats either ate high fat (60% kcal from fat) chow and drank water or ate standard (17% kcal from fat) chow and drank either water, a 10% sucrose solution, or a 0.1% saccharin solution. The rats either had continuous access to high fat chow, sucrose, or saccharin, or had intermittent access (i.e. 2 days/week) to these substances, with access to water and standard chow on other days. As compared with standard chow, continuous (but not intermittent) access to high fat chow enhanced the development of sensitization to cocaine-induced (1-17.8 mg/kg) locomotion; drinking sucrose or saccharin (continuous or intermittent access) did not alter the development of sensitization to cocaine-induced locomotion. The impact of feeding condition on the behavioral effects of cocaine varies between sexes and across dietary composition.
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Registered trials
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