Evidence map›Paper›PMID 25485468›Full record

ReviewAnesthesiology2015

Acute and perioperative care of the burn-injured patient.

Edward A Bittner, Erik Shank, Lee Woodson, J A Jeevendra Martyn

2 registry-linked trialsAbstract readReview
In one paragraph

Review in Anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06459076 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Application of Transnasal Humidified Rapid-insufflation Ventilatory Exchange (THRIVE) in Burn Children With Suspected Difficult Airway:A Single-center, Randomized Controlled Study

TypeinterventionalSponsorShuxiu WangRan2024 to 2026Enrolled120ConditionsIntubation, Difficult or FailedArmsTransnasal humidified rapid-insufflation ventilatory exchange (THRIVE)
NCT06766474 phase2completednot on this mapstarted 2023, after this paper: background citation

Bupivacaine Hydrochloride-Soaked Dressing Versus Subcutaneous Infiltration for Postoperative Analgesia in Skin Graft Donor Site: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorMinia UniversityRan2023 to 2024Enrolled90ConditionsSkin Graft Complications, Pain ManagementArmsBupivacain
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Quality of Life, PTSD, and Insomnia in Patients with Burn Injuries.Advances in experimental medicine and biology · 2026
    Article
  9. Review of the 100 Most Cited Articles inEuropean burn journal · 2025
    Review
  10. Pathophysiology and management of burn injury-induced pain.Burns open : an international open access journal for burn injuries · 2025
    Article
  11. Prehospital and emergency data analysis in burn patients: Mortality predictors and response times over five years.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Edward A BittnerFrom the Department of Anesthesiology, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (E.A.B., E.S., J.A.J.M.); Shriners Hospitals for Children®, Boston, Massachusetts (E.A.B., E.S., J.A.J.M.); Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas (L.W.); and Shriners Hospitals for Children®, Galveston, Texas (L.W.).
Erik Shank
Lee Woodson
J A Jeevendra Martyn

Funding

WOUND HEALINGP50GM021700 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI TOMPKINS, RONALD GARY · 1985 to 2017
$27.2M
NIGMS NIH HHS P50 GM021700NIGMS NIH HHS P50-GM 2500
6 · The paper itself

Abstract

Care of burn-injured patients requires knowledge of the pathophysiologic changes affecting virtually all organs from the onset of injury until wounds are healed. Massive airway and/or lung edema can occur rapidly and unpredictably after burn and/or inhalation injury. Hemodynamics in the early phase of severe burn injury is characterized by a reduction in cardiac output and increased systemic and pulmonary vascular resistance. Approximately 2 to 5 days after major burn injury, a hyperdynamic and hypermetabolic state develops. Electrical burns result in morbidity much higher than expected based on burn size alone. Formulae for fluid resuscitation should serve only as guideline; fluids should be titrated to physiologic endpoints. Burn injury is associated basal and procedural pain requiring higher than normal opioid and sedative doses. Operating room concerns for the burn-injured patient include airway abnormalities, impaired lung function, vascular access, deceptively large and rapid blood loss, hypothermia, and altered pharmacology.

Indexed as

AnesthesiaBurnsBurns, ElectricBurns, InhalationHumansPain ManagementPerioperative Care

Identifiers

PMID25485468
PMCPMC4844008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.