Evidence map›Paper›PMID 25485229›Full record

ArticleJournal of obsessive-compulsive and related disorders2015

REDUCED DISGUST PROPENSITY IS ASSOCIATED WITH IMPROVEMENT IN CONTAMINATION/WASHING SYMPTOMS IN OBSESSIVE-COMPULSIVE DISORDER.

Alison J Athey, Jason A Elias, Jesse M Crosby, Michael A Jenike, Harrison G Pope, James I Hudson, Brian P Brennan

Open access · greenAbstract read
In one paragraph

Article in Journal of obsessive-compulsive and related disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alison J AtheyBiological Psychiatry Laboratory, McLean Hospital, Belmont, MA.
Jason A EliasObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA.
Jesse M CrosbyObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA.
Michael A JenikeObsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA.
Harrison G PopeBiological Psychiatry Laboratory, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA.
James I HudsonBiological Psychiatry Laboratory, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA.
Brian P BrennanBiological Psychiatry Laboratory, McLean Hospital, Belmont, MA ; Obsessive-Compulsive Disorder Institute, McLean Hospital, Belmont, MA ; Department of Psychiatry, Harvard Medical School, Boston, MA.
McLean Hospital · US

Funding

Glutamatergic Mediators of Antidepressant Response in Major DepressionK23MH092397 · NIMH · MCLEAN HOSPITAL · PI BRENNAN, BRIAN P. · 2011 to 2015
$895k
NIMH NIH HHS K23 MH092397
6 · The paper itself

Abstract

objectivesDisgust is a well-established phenomenon with known neurobiological correlates. However, it remains unclear how or whether disgust changes with clinical treatment, because few longitudinal studies have tracked the association of disgust vulnerability and clinical symptoms in patient populations.

methodsWe assessed disgust propensity and symptoms of obsessive-compulsive disorder (OCD) in 134 patients receiving intensive residential treatment for OCD. Using linear regression with adjustment for age, sex, and depression severity, we tested the association between change in disgust propensity and change in OCD symptoms from admission to discharge.

resultsChange in disgust propensity was significantly associated with improvement in contamination/washing symptoms (β = 0.25 [95% confidence interval: 0.11-0.39];

conclusionsIn patients with OCD undergoing intensive residential treatment, disgust propensity appears to improve in parallel with contamination/washing symptoms.

Indexed as

contaminationdisgustobsessive-compulsive disorderOCD

Identifiers

PMID25485229
PMCPMC4254727
OpenAlexW1992234438

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.