Evidence map›Paper›PMID 25485183›Full record

ArticleJournal of biomolecular research & therapeutics2014

Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs.

Kelly Teske, Premchendar Nandhikonda, Jonathan W Bogart, Belaynesh Feleke, Preetpal Sidhu, Nina Yuan, Joshua Preston, Robin Goy, Leggy A Arnold

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomolecular research & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kelly TeskeDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Premchendar NandhikondaDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Jonathan W BogartDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Belaynesh FelekeDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Preetpal SidhuDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Nina YuanDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Joshua PrestonDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Robin GoyDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
Leggy A ArnoldDepartment of Chemistry and Biochemistry, University of Wisconsin-Milwaukee, WI 53211, USA.
University of Wisconsin–Milwaukee · US

Funding

Vitamin D Receptor Coactivators in KeratinocytesR01AR050023 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI BIKLE, DANIEL DAVID · 2004 to 2014
$3.4M
Small molecule inhibitors of the vitamin D receptor-coactivator interactionR03DA031090 · NIDA · UNIVERSITY OF WISCONSIN MILWAUKEE · PI ARNOLD, ALEXANDER · 2010 to 2011
$73k
NIAMS NIH HHS R01 AR050023NIDA NIH HHS R03 DA031090
6 · The paper itself

Abstract

Herein we describe the evaluation of GW0742 analogs in respect to their ability to modulate transcription mediated by the vitamin D receptor (VDR) and the peroxisome proliferator activated receptor (PPAR) δ. The GW0742 analog bearing a carboxylic ester functionality in place of the carboxylic acid was partially activating both nuclear receptors at low concentration and inhibited transcription at higher compound concentrations. The GW0742 alcohol derivative was more active than the ester in respect to VDR but less active in regard to PPARδ. Importantly, the alcohol derivative was significantly more toxic than the corresponding acid and ester.

Identifiers

PMID25485183
PMCPMC4255951
OpenAlexW2186728601

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.